425380-37-6

Basic information

• Product Name: 4-BROMO-7-METHOXY-6-AZAINDOLE
• Synonyms: 4-BROMO-7-METHOXY-6-AZAINDOLE;4-Bromo-7-methoxy-1H-pyrrolo[2,3-c]pyridine;1H-Pyrrolo[2,3-c]pyridine, 4-broMo-7-Methoxy-
• CAS NO: 425380-37-6
• Molecular Formula: C8H7BrN2O
• Molecular Weight: 227.06
• Mol File: 425380-37-6.mol
• Article Data: 29

Chemical Properties

• Melting Point: 174-175°
• Boiling Point: 347.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.678±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.22±0.40(Predicted)
• CAS DataBase Reference: 4-BROMO-7-METHOXY-6-AZAINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-7-METHOXY-6-AZAINDOLE(425380-37-6)
• EPA Substance Registry System: 4-BROMO-7-METHOXY-6-AZAINDOLE(425380-37-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 425380-37-6(Hazardous Substances Data)

Usage

General Description

4-Bromo-7-methoxy-6-azaindole is a chemical compound with the molecular formula C9H8BrN2O. It is a bromine-substituted derivative of 6-azaindole, and its structure includes a methoxy group. 4-BROMO-7-METHOXY-6-AZAINDOLE has been studied for its potential applications in pharmaceutical research, particularly in the development of new drugs for various medical conditions. It is also used as a building block in the synthesis of other organic molecules, due to its unique structure and reactivity. 4-Bromo-7-methoxy-6-azaindole is considered a valuable compound in the field of chemistry and is the subject of ongoing research for its potential therapeutic uses.

Upstream product

• 865-33-8 potassium methanolate 
• 425380-38-7 4-bromo-7-chloro-3a,7a-dihydro-1H-pyrrolo[2,3-c]pyridine 
• 23056-39-5 2-chloro-3-nitro-4-methylpyridine 
• 160590-36-3 2-methoxy-4-methyl-3-nitropyridine 
• 884495-14-1 5-bromo-2-methoxy-4-methyl-3-nitropyridine 
• 64-19-7 acetic acid 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 917918-81-1 2-(5-bromo-2-methoxy-3-nitropyridin-4-yl)-N,N-dimethylethenamine 
• 1826-67-1 vinyl magnesium bromide 
• 152684-30-5 5-bromo-2-methoxy-3-nitropyridine 
• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 
• 124-41-4 sodium methylate 

Downstream Products

• 1446232-71-8 N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]propane-1-sulfonamide 
• 1446232-72-9 2,2,2-trifluoro-N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]ethanesulfonamide 
• 1445992-74-4 ethyl 3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxybenzoate 
• 1445992-76-6 3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxybenzoic acid 
• 1445992-84-6 3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxy-N-(tetrahydrofuran-2-ylmethyl)benzamide 
• 1446235-06-8 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one 
• 1445993-87-2 4-bromo-6-methyl-1-[(4-methylphenyl)sulfonyl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one 
• 1445993-88-3 4-(2-fluoro-5-nitrophenyl)-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]-pyridin-7(6H)-one 
• 1445992-62-0 6-methyl-4-(2-phenoxyphenyl)-1,6-dihydro-7H-pyrrolo[2,3-c]-pyridin-7-one 
• 1445993-30-5 ethyl 4-(cyclopentylamino)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzoate 
• 1445992-63-1 6-methyl-4-(5-nitro-2-phenoxyphenyl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one 
• 1445993-86-1 4-bromo-1-[(4-methylphenyl)sulfonyl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one 
• 1445992-64-2 4-(5-amino-2-phenoxyphenyl)-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one 
• 1445993-51-0 6-methyl-4-[2-(morpholin-4-ylcarbonyl)phenyl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one 

Relevant articles and documents

NOVEL HETEROCYCLIC COMPOUNDS AS BET INHIBITORS

Provided are heterocyclic compounds of formula (I) as bromodomain and extraterminal (BET) inhibitors, pharmaceutical compositions comprising the compounds, their synthesis and their use for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.

Compound with BRD4 inhibitory activity, preparation method and application thereof

The invention discloses a compound with BRD4 inhibitory activity, a preparation method and application thereof. The structure of the compound with the BRD4 inhibitory activity is shown as a formula I, and definitions of substituent groups are shown in the specification and claims. The compound provided by the invention has very high bromodomain protein inhibition activity, especially BRD4 targeted inhibition activity, and can be used for treating or/and preventing related diseases mediated by bromodomain protein.

Pyrrolopyridone compound as well as preparation method, composition and application thereof

The invention relates to a pyrrolopyridone compound or pharmaceutically acceptable salts thereof, and a preparation method and application thereof. The pyrrolopyridone compound has a structure as shown in a formula I which is described in the specification. The compound has the characteristic of BRD4 and HDAC double-target inhibition activity and/or has the characteristic of a function of targetedubiquitination degradation of BRD4 protein, and can be applied to related diseases such as tumor resistance related to the target.