1446114-06-2Relevant academic research and scientific papers
Synthesis of a human urate transporter-1 inhibitor, an arginine vasopressin antagonist, and a 17β-hydroxysteroid dehydrogenase type-3 inhibitor, using ring-expansion of cyclic ketoximes with DIBALH
Cho, Hidetsura,Iwama, Yusuke,Okano, Kentaro,Tokuyama, Hidetoshi
, p. 354 - 363 (2014/04/17)
Synthesis of three clinical candidates for medicines, a human urate transporter-1 inhibitor, an arginine vasopressin antagonist, and a 17β-hydroxysteroid dehydrogenase type-3 inhibitor, is described. These compounds were synthesized via construction of their 3,4-dihydro-2H-benzo[b][1, 4]oxazine, dibenzodiazepine, and dibenzazocine skeletons, respectively, using the reductive ring-expansion reaction of the corresponding bicyclic or tricyclic oximes with diisobutylaluminum hydride.
Construction of Dibenzazocine Skeleton by Regiocontrolled Ring-Expansion Reaction of Cyclic Oxime with DIBAL-H: Facile Synthesis of 17β-Hydroxy- steroid Dehydrogenase Type 3 Inhibitor
Cho, Hidetsura,Iwama, Yusuke,Okano, Kentaro,Tokuyama, Hidetoshi
, p. 813 - 816 (2013/05/22)
Synthetic studies on a 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor are described. The unsymmetrical dibenzazocine skeleton was constructed by a regiocontrolled ring-expansion reaction of a cyclic oxime with DIBAL-H. Georg Thieme Verlag Stuttgart · New York.
