1446121-35-2

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 131685-53-5 (S)-4-benzyl-3-propionyl-2-oxazolidinone 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 1446121-97-6 (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-p-tolyl-oxacyclododec-4-en-6-yl acetate 
• 1446121-87-4 (4R,7R,8S,11S,12S,E)-4,7,8-trihydroxy-7,11-dimethyl-12-p-tolyl-oxacyclododec-9-en-2-one 
• 1446121-75-0 (3R,6R,7S)-((1S,2S)-2-methyl-1-p-tolylbut-3-enyl) 3,6,7-trihydroxy-6-methylnon-8-enoate 
• 1446121-63-6 (R)-((1S,2S)-2-methyl-1-p-tolylbut-3-enyl)-3-(tert-butyldimethylsilyl-oxy)-5-((4R,5S)-2,2,4-trimethyl-5-vinyl-1,3-dioxolan-4-yl)pentanoate 
• 1446121-49-8 tert-butyldimethyl((1S,2S)-2-methyl-1-p-tolylbut-3-enyloxy)silane 
• 1446121-42-1 (2S,3S)-3-(tert-butyldimethylsilyloxy)-2-methyl-3-p-tolylpropan-1-ol 

Relevant academic research and scientific papers

Enantioselective synthesis of pladienolide B and truncated analogues as new anticancer agents

An enantioselective synthesis of natural anticancer macrolide pladienolide B is described. The synthetic highlights include Sharpless asymmetric epoxidation, ring closing metathesis (RCM), Ireland-Claisen rearrangement, Shi epoxidation, and Pd-catalyzed S