1446121-75-0

Upstream product

• 1446120-41-7 (R)-3-(tert-butyldimethylsilyloxy)-5-((4R,5S)-2,2,4-trimethyl-5-vinyl-1,3-dioxolan-4-yl)pentan-1-ol 
• 1446120-32-6 (R)-5-(2-((4R,5S)-5-(benzyloxymethyl)-2,2,4-trimethyl-1,3-dioxolan-4-yl)ethyl)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecane 
• 1446120-21-3 (E)-5-((4R,5S)-5-(benzyloxymethyl)-2,2,4-trimethyl-1,3-dioxolan-4-yl)pent-2-en-1-ol 
• 1446120-13-3 3-((4R,5S)-5-(benzyloxymethyl)-2,2,4-trimethyl-1,3-dioxolan-4-yl)propanal 
• 304465-95-0 (2S,3R)-1-(benzyloxy)-3,7-dimethyloct-6-ene-2,3-diol 
• 106-24-1 Geraniol 
• 1446120-44-0 (R)-3-(tert-butyldimethylsilyloxy)-5-((4R,5S)-2,2,4-trimethyl-5-vinyl-1,3-dioxolan-4-yl)pentanoic acid 
• 1446121-63-6 (R)-((1S,2S)-2-methyl-1-p-tolylbut-3-enyl)-3-(tert-butyldimethylsilyl-oxy)-5-((4R,5S)-2,2,4-trimethyl-5-vinyl-1,3-dioxolan-4-yl)pentanoate 
• 1446121-49-8 tert-butyldimethyl((1S,2S)-2-methyl-1-p-tolylbut-3-enyloxy)silane 
• 1446121-42-1 (2S,3S)-3-(tert-butyldimethylsilyloxy)-2-methyl-3-p-tolylpropan-1-ol 
• 104-87-0 4-methyl-benzaldehyde 
• 1446120-38-2 (R)-2,2,3,3,9,9,10,10-octamethyl-5-(2-((4R,5S)-2,2,4-trimethyl-5-vinyl-1,3-dioxolan-4-yl)ethyl)-4,8-dioxa-3,9-disilaundecane 
• 1446120-35-9 ((4S,5R)-5-((R)-3,5-bis(tert-butyldimethylsilyloxy)pentyl)-2,2,5-tri-methyl-1,3-dioxolan-4-yl)methanol 
• 1446121-35-2 (S)-4-benzyl-3-((2R,3S)-3-(tert-butyldimethylsilyloxy)-2-methyl-3-p-tolylpropanoyl)oxazolidin-2-one 

Downstream Products

• 1446121-87-4 (4R,7R,8S,11S,12S,E)-4,7,8-trihydroxy-7,11-dimethyl-12-p-tolyl-oxacyclododec-9-en-2-one 
• 1446121-97-6 (2S,3S,6S,7R,10R,E)-7,10-dihydroxy-3,7-dimethyl-12-oxo-2-p-tolyl-oxacyclododec-4-en-6-yl acetate 

Relevant academic research and scientific papers

Enantioselective synthesis of pladienolide B and truncated analogues as new anticancer agents

An enantioselective synthesis of natural anticancer macrolide pladienolide B is described. The synthetic highlights include Sharpless asymmetric epoxidation, ring closing metathesis (RCM), Ireland-Claisen rearrangement, Shi epoxidation, and Pd-catalyzed S