1446186-36-2Relevant academic research and scientific papers
Cycloaddition-based formal C-H alkynylation of isoindoles leading to the synthesis of air-stable fluorescent 1,3-dialkynylisoindoles
Ohmura, Toshimichi,Kijima, Akihito,Komori, Yusuke,Suginome, Michinori
, p. 3510 - 3513 (2013/08/23)
Reaction of N-alkylisoindoles with (bromoethynyl)triisopropylsilane afforded 1,3-bis(triisopropylsilylethynyl) isoindoles in high yields. The formal C-H alkynylation proceeds under transition-metal-free conditions through [4 + 2] cycloaddition of the pyrrole ring of isoindole with bromoalkyne followed by ring-opening of the product.
