144625-34-3

Basic information

• Product Name: 1-[(2'-carboxamidobiphenyl-4-yl)methyl]-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one
• Synonyms: 1-[(2'-carboxamidobiphenyl-4-yl)methyl]-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one
• CAS NO: 144625-34-3
• Molecular Weight: 403.524
• Mol File: 144625-34-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-[(2'-carboxamidobiphenyl-4-yl)methyl]-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2'-carboxamidobiphenyl-4-yl)methyl]-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one(144625-34-3)
• EPA Substance Registry System: 1-[(2'-carboxamidobiphenyl-4-yl)methyl]-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one(144625-34-3)

Safety Data

• Hazardous Substances Data: 144625-34-3(Hazardous Substances Data)

Upstream product

• 945540-18-1 4-[(α-N-pentanoylamino)cyclopentamidomethyl]-2'-carboxamidobiphenyl 
• 15026-80-9 N-pentanoylaminocyclopentane-1-carboxylic acid 
• 866946-42-1 2-(4-aminomethylphenyl)benzamide 
• 133690-92-3 [(2'-cyanobiphenyl-4-yl)methyl]amine 

Downstream Products

• 138402-11-6 2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one 
• 138401-24-8 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE PREPARATION OF IRBESARTAN

The present invention relates to an improved process for the preparation of 2-n-butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]-1,3-diazaspiro[4.4]non-1-en-4-one (Irbesartan)

AN IMPROVED PROCESS FOR PREPARATION OF IRBESARTAN

A process for the preparation of Irbesartan of formula (I): Formula (I) comprising the steps of: (i) reacting 4' aminomethyl-2-cyano biphenyl of formula (VI) with 1-veleramido cyclopentane carboxylic acid of formula (V): Formula (VI) and Formula (V) in an organic solvent and in the presence of an acid, without activating the -COOH group of compound of formula (V) to give 1-(2'cyanobiphenyl-4-yl-methylaminocarbonyl)-1-pentanoylamino cyclopentane of formula (VII). Formula (VII) converting the compound of formula (VII) obtained in step (i) to Irbesartan of formula (I) by reacting the compound of the formula (VII) with tributyl tin azide in o-xylene to give Irbesartan of formula (I).