15026-80-9

Basic information

• Product Name: Cyclopentanecarboxylic acid, 1-[(1-oxopentyl)amino]-
• CAS NO: 15026-80-9
• Molecular Formula: C11H19NO3
• Molecular Weight: 213.277
• Mol File: 15026-80-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Cyclopentanecarboxylic acid, 1-[(1-oxopentyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanecarboxylic acid, 1-[(1-oxopentyl)amino]-(15026-80-9)
• EPA Substance Registry System: Cyclopentanecarboxylic acid, 1-[(1-oxopentyl)amino]-(15026-80-9)

Safety Data

• Hazardous Substances Data: 15026-80-9(Hazardous Substances Data)

Usage

General Description

Cyclopentanecarboxylic acid, 1-[(1-oxopentyl)amino]-, also known as cyclopentanecarboxylic acid 1-(1-oxopentyl)-5-amino, is a chemical compound with the molecular formula C10H17NO3. It is a derivative of cyclopentane and carboxylic acid, containing an amino group and a ketone group. Cyclopentanecarboxylic acid, 1-[(1-oxopentyl)amino]- is commonly used in the pharmaceutical and medical industry as an intermediate in the synthesis of various drugs and pharmaceuticals. It can also be utilized in research and development for its potential therapeutic properties. However, it is important to handle this chemical with caution due to its potential hazards and toxicity.

Upstream product

• 92398-48-6 1-aminocyclopentanecarboxylic acid hydrochloride 
• 638-29-9 n-valeryl chloride 
• 16195-83-8 1-aminocyclopentanecarbonitrile hydrochloride 
• 194984-24-2 1-cyano-1-n-pentanoylaminocyclopentane 
• 52-52-8 1-amino-1-cyclopentanecarboxylic acid 

Downstream Products

• 141745-71-3 1-pentanoylamino-cyclopentanecarboxylic acid (2'-cyano-biphenyl-4-ylmethyl)-amide 
• 138402-11-6 2-butyl-3-{4-[2-(1H-tetrazol-5-yl)phenyl]benzyl}-1,3-diazaspiro[4.4]non-1-en-4-one 
• 935477-52-4 2-(n-butyl)-3-[2'-(1,3-oxazolin-4,4-dimethyl)-biphenyl-4-ylmethyl]-4-oxo-1,3-diazaspiro[4.4]non-1-ene-4-one 
• 144625-34-3 1-[(2'-carboxamidobiphenyl-4-yl)methyl]-2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one 
• 138402-10-5 trityl irbesartan 
• 138401-24-8 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile 
• 908117-90-8 1-pentanoylamine-cyclopentanocarboxylic acid 4-iodobenzylamide 
• 945540-18-1 4-[(α-N-pentanoylamino)cyclopentamidomethyl]-2'-carboxamidobiphenyl 
• 15026-81-0 2-butyl-3-oxa-1-aza-spiro[4.4]non-1-en-4-one 

Relevant articles and documents

AN IMPROVED PROCESS FOR PREPARING 1-(PENTANOYLAMINO)CYCLOPENTANECARBOXYLIC ACID

The present invention relates to an improved process for preparing 1-(pentanoylamino)cyclopentanecarboxylic acid formula (I) which is useful intermediate for the preparation of Irbesartan.

AN IMPROVED PROCESS FOR PREPARATION OF IRBESARTAN

A process for the preparation of Irbesartan of formula (I): Formula (I) comprising the steps of: (i) reacting 4' aminomethyl-2-cyano biphenyl of formula (VI) with 1-veleramido cyclopentane carboxylic acid of formula (V): Formula (VI) and Formula (V) in an organic solvent and in the presence of an acid, without activating the -COOH group of compound of formula (V) to give 1-(2'cyanobiphenyl-4-yl-methylaminocarbonyl)-1-pentanoylamino cyclopentane of formula (VII). Formula (VII) converting the compound of formula (VII) obtained in step (i) to Irbesartan of formula (I) by reacting the compound of the formula (VII) with tributyl tin azide in o-xylene to give Irbesartan of formula (I).

A new entry to antihypertensive active pharmaceutical ingredient, Irbesartan and its analogues

A new synthesis of Irbesartan, an antihypertensive active pharmaceutical ingredient and its analogues is reported.