1446282-00-3

Upstream product

• 610-81-1 4-hydroxy-2-nitroaniline 
• 59820-64-3 ethyl 2-(4-amino-3-nitrophenoxy)acetate 
• 1446281-99-7 ethyl 2-[3-nitro-4-(2-piperidylacetylamino)phenoxy]acetate 

Downstream Products

• 1446282-01-4 ethyl 2-(3-{[2-(2,6-dimethylphenoxy)ethyl]amino}-4-(2-piperidylacetylamino)phenoxy)acetate 
• 1446281-88-4 {1-[2-(2,6-dimethylphenoxy)ethyl]-2-piperidin-1-ylmethyl-1H-benzimidazol-6-yloxy}acetic acid ethyl ester 

Relevant academic research and scientific papers

BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT

The present invention is directed to methods of treating diseases or conditions mediated by elevated persistent sodium channel, such as ocular disorders, pain, multiple sclerosis, and seizure disorders utilizing a compound of Formula I or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising said compound, wherein variables R, R1, R2, R3, R4, R5, m, and n in Formula I are as defined herein