59820-64-3

Upstream product

• 623-50-7 ethyl 2-hydroxyacetate 
• 610-81-1 4-hydroxy-2-nitroaniline 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1446282-00-3 ethyl 2-[3-amino-4-(2-piperidylacetylamino)phenoxy]acetate 
• 1446282-01-4 ethyl 2-(3-{[2-(2,6-dimethylphenoxy)ethyl]amino}-4-(2-piperidylacetylamino)phenoxy)acetate 
• 1446281-88-4 {1-[2-(2,6-dimethylphenoxy)ethyl]-2-piperidin-1-ylmethyl-1H-benzimidazol-6-yloxy}acetic acid ethyl ester 
• 1446281-99-7 ethyl 2-[3-nitro-4-(2-piperidylacetylamino)phenoxy]acetate 
• 59820-55-2 2-(3-arnino-4-nitrophenoxy)acetic acid 
• 840531-42-2 ethyl (4-({3-[amino(imino)methyl]benzoyl}amino)-3-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}phenoxy)acetate 

Relevant academic research and scientific papers

Discovery of carbazole derivatives as novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening

We report in this work the discovery of novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening. Two out of 13 virtual hit compounds were identified as MEK kinase inhibitors using a MEK1 binding assay. Structural derivations on the

With MEK kinase inhibiting compound of the function and its preparation method and application

The invention discloses a compound with an MEK kinase inhibition function, and a preparation method and application thereof. The chemical structure of the compound is as shown in a formula I which is described in the specification. Moreover, the invention provides the preparation method for the compound. Research shows that the compound has good MEK kinase inhibition activity and has wide application values in fields related to an MEK kinases inhibitor.

Easy conjugations between molecules via copper-catalyzed reactions of ortho-aromatic diamines with ketones

It is a great challenge to achieve a useful reaction under benign conditions. In this paper, a highly efficient method for copper-catalyzed conjugations of o-aromatic diamines with ketones has been developed using benign chemistry. Interestingly, the conjugation between the biological small molecules worked very well.

BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT

The present invention is directed to methods of treating diseases or conditions mediated by elevated persistent sodium channel, such as ocular disorders, pain, multiple sclerosis, and seizure disorders utilizing a compound of Formula I or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising said compound, wherein variables R, R1, R2, R3, R4, R5, m, and n in Formula I are as defined herein

Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors

Factor Xa (fXa) is a serine protease that plays a pivotal role in the coagulation cascade. High-throughput screening of the Yamanouchi compound library yielded lead compound 1 with the ability to inhibit fXa at micromolar concentrations. To improve its fX