1446282-38-7 Usage
Uses
Used in Pharmaceutical Industry:
Ald-PEG5-Azide is used as a crosslinking agent for the development of novel drug conjugates and targeted therapies. The ability to form stable bonds with peptides and proteins through the aldehyde group allows for the creation of bioconjugates with improved pharmacokinetic properties, such as enhanced solubility, stability, and circulation time in the body. This can lead to more effective drug delivery and reduced side effects.
Used in Bioconjugation and Labeling:
In the field of bioconjugation and labeling, Ald-PEG5-Azide is used as a versatile linker to attach various functional groups, such as fluorescent dyes, enzymes, or other biomolecules, to peptides and proteins. The click chemistry-based PEGylation allows for the formation of stable and specific conjugates, which can be used for a variety of applications, including imaging, diagnostics, and therapeutics.
Used in Drug Delivery Systems:
Ald-PEG5-Azide is employed as a component in the design of drug delivery systems, such as nanoparticles, liposomes, and hydrogels. The PEGylation provided by Ald-PEG5-Azide can improve the solubility, stability, and bioavailability of drug-loaded carriers, leading to enhanced therapeutic outcomes. Additionally, the aldehyde group can be used to attach targeting ligands to the drug delivery system, enabling selective delivery to specific cells or tissues.
Used in Materials Science:
In the field of materials science, Ald-PEG5-Azide can be utilized as a building block for the development of novel biocompatible materials and coatings. The ability to form stable covalent bonds with a variety of molecules allows for the creation of materials with tailored properties, such as improved biocompatibility, reduced immunogenicity, and enhanced cell adhesion or growth.
Used in Research and Development:
Ald-PEG5-Azide is also used as a valuable tool in research and development, particularly in the fields of molecular biology, biochemistry, and chemical biology. The click chemistry-based PEGylation and the ability to form stable bonds with peptides and proteins make it an attractive option for the creation of novel bioconjugates, probes, and sensors for various research applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1446282-38-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,6,2,8 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1446282-38:
(9*1)+(8*4)+(7*4)+(6*6)+(5*2)+(4*8)+(3*2)+(2*3)+(1*8)=167
167 % 10 = 7
So 1446282-38-7 is a valid CAS Registry Number.
1446282-38-7Relevant academic research and scientific papers
CONJUGATES COMPRISING SELF-IMMOLATIVE GROUPS AND METHODS RELATED THERETO
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Page/Page column 96; 97, (2017/06/27)
In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self- immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
CONJUGATES COMPRISING PEPTIDE GROUPS AND METHODS RELATED THERETO
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Page/Page column 107; 108, (2017/08/08)
In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and at least two active agents. In preferred embodiments, the linker comprises a peptide sequence of a plurality of amino acids, and at least two of the active agents are covalently coupled to side chains of the amino acids. The antibody-drug conjugate may comprise a self-immolative group, preferably two-self-immolative groups. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
