1446282-38-7 Usage
Description
Ald-CH2-PEG5-azide is a click chemistry crosslinker containing an azide group and an aldehyde group. The azide group enables PEGylation via Click Chemistry. PEG5 arm increases solubility in aqueous media. The aldehyde group reacts with amines and the N-terminal of peptides and proteins to form an imine containing a C=N double bond, which can be further reduced.
Check Digit Verification of cas no
The CAS Registry Mumber 1446282-38-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,6,2,8 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1446282-38:
(9*1)+(8*4)+(7*4)+(6*6)+(5*2)+(4*8)+(3*2)+(2*3)+(1*8)=167
167 % 10 = 7
So 1446282-38-7 is a valid CAS Registry Number.
1446282-38-7Relevant articles and documents
CONJUGATES COMPRISING SELF-IMMOLATIVE GROUPS AND METHODS RELATED THERETO
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Page/Page column 96; 97, (2017/06/27)
In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self- immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
