1446321-52-3

Upstream product

• 1446322-02-6 3-((tert-butyldimethylsilyloxy)methyl)-2-(1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl)pyridine 
• 1446321-98-7 (2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridin-3-yl)methanol 
• 1446321-97-6 3-((tert-butyldimethylsilyloxy)methyl)-2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridine 
• 1446321-92-1 (E)-1-(3-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-2-yl)-3-(dimethylamino)prop-2-en-1-one 
• 1446321-91-0 1-(3-((tert-butyldimethylsilyloxy)methyl)pyridin-2-yl)ethanone 
• 210037-84-6 3-{[(tert-butyldimethylsilyl)oxy]methyl}pyridine-2-carbonitrile 
• 524019-50-9 2-bromo-3-(((tert-butyldimethylsilyl)oxy)methyl)pyridine 
• 131747-54-1 (2-bromopyrid-3-yl)methanol 
• 35905-85-2 2-bromonicotinic acid 
• 387-46-2 2,6-dihydroxybenzaldehyde 
• 1446321-99-8 3-(chloromethyl)-2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyridine hydrochloride 

Relevant academic research and scientific papers

Compounds and uses thereof for the modulation of hemoglobin

Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.