1446327-79-2

Basic information

• Product Name: 3-(5-phenyl-1,2,4-oxadiazol-3-yl)-7-(piperazin-1-yl)-2H-chromen-2-one
• Synonyms: 3-(5-phenyl-1,2,4-oxadiazol-3-yl)-7-(piperazin-1-yl)-2H-chromen-2-one
• CAS NO: 1446327-79-2
• Molecular Weight: 374.399
• Mol File: 1446327-79-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(5-phenyl-1,2,4-oxadiazol-3-yl)-7-(piperazin-1-yl)-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-phenyl-1,2,4-oxadiazol-3-yl)-7-(piperazin-1-yl)-2H-chromen-2-one(1446327-79-2)
• EPA Substance Registry System: 3-(5-phenyl-1,2,4-oxadiazol-3-yl)-7-(piperazin-1-yl)-2H-chromen-2-one(1446327-79-2)

Safety Data

• Hazardous Substances Data: 1446327-79-2(Hazardous Substances Data)

Upstream product

• 1446332-69-9 tert-butyl 4-(4-formyl-3-hydroxyphenyl)piperazine-1-carboxylate 
• 348-28-7 4-fluoro-2-hydroxybenzaldehyde 
• 1446333-16-9 tert-butyl 4-(2-oxo-3-(5-phenyl-1,2,4-oxadiazol-3-yl)-2H-chromen-7-yl)piperazine-1-carboxylate 
• 1446333-14-7 tert-butyl 4-(3-(N'-hydroxycarbamimidoyl)-2-oxo-2H-chromen-7-yl)piperazine-1-carboxylate 
• 1446333-12-5 tert-butyl 4-(3-cyano-2-oxo-2H-chromen-7-yl)piperazine-1-carboxylate 

Relevant articles and documents

Compounds for treating spinal muscular atrophy

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.