1446438-01-2

Upstream product

• 104-55-2 3-phenyl-propenal 
• 950740-50-8 (2S,3R,4S)-3,4-bis(benzyloxy)-2-(benzyloxymethyl)-3,4-dihydro-2H-pyrrole-1-oxide 
• 1446437-78-0 (1R,5S,6R,7S,7aS)-6,7-bis(benzyloxy)-5-((benzyloxy)methyl)-1-phenyltetrahydro-1H-pyrrolizin-3(2H)-one 

Relevant academic research and scientific papers

NHC-mediated cross-coupling of sugar-derived cyclic nitrones with enals: General and efficient synthesis of polyhydroxylated pyrrolizidines and indolizidines

A general and efficient method for the synthesis of polyhydroxylated pyrrolizidines and indolizidines has been developed based on the NHC-catalyzed cross-coupling of sugar-derived cyclic nitrones with enals, which afforded the key intermediates, γ-hydroxyl amino esters, in good to excellent yields. Thus, a variety of polyhydroxylated pyrrolizidines and indolizidines have been synthesized and assayed against various glycosidases, which showed that aryl or alkyl substituents at C-7 of pyrrolizidines or at C-8 of indolizidines reduced the potency of the glycosidase inhibition of these bicyclic iminosugars. is