1446482-09-2

Basic information

• Product Name: C₁₈H₂₅NO₄
• Synonyms: C₁₈H₂₅NO₄
• CAS NO: 1446482-09-2
• Molecular Weight: 319.401
• Mol File: 1446482-09-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₅NO₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₅NO₄(1446482-09-2)
• EPA Substance Registry System: C₁₈H₂₅NO₄(1446482-09-2)

Safety Data

• Hazardous Substances Data: 1446482-09-2(Hazardous Substances Data)

Upstream product

• 1446482-08-1 C₁₀H₁₇NO₂S 
• 1446482-07-0 C₁₀H₁₇NO₃ 
• 1446482-06-9 1-tert-butyl 4-ethyl 2-cyano-2-methylbutanedioate 
• 66476-82-2 tert-butyl 2-cyanopropionate 

Downstream Products

• 1410783-77-5 (R)-3-methylpyrrolidine-3-carboxylic acid 
• 912444-75-8 1-((benzyloxy)carbonyl)-3-methylpyrrolidine-3-carboxylic acid 
• 885953-27-5 3-methylpyrrolidine-3-carboxylic acid 

Relevant articles and documents

Asymmetric synthesis and catalytic activity of 3-methyl-β-proline in enantioselective anti -mannich-type reactions

Enantiomerically pure 3-methyl-β-proline was synthesized using an asymmetric phase-transfer-catalyzed alkylation of a cyanopropanoate to establish the all-carbon stereogenic center. The catalytic activity of 3-methyl-β-proline in the Mannich-type reaction between a glyoxylate imine and ketones/aldehydes was subsequently investigated. The catalyst was designed and found to be more soluble in nonpolar organic solvents relative to the unsubstituted β-proline catalyst, and as a result allowed for added flexibility during optimization efforts. This work culminated in the development of a highly anti-diastereo- and enantioselective process employing low catalyst loading.