1446671-28-8Relevant articles and documents
Synthesis of azaheterocyclic vinylphosphonates by ring-closing metathesis
Garzon, Cecile,Attolini, Mireille,Maffei, Michel
, p. 3653 - 3657 (2013/07/19)
The title compounds were synthesized by ruthenium-catalyzed ring-closing metathesis of N-tosyl-N-(ω-alkenyl)aminomethylvinyl phosphonates, which were obtained from N-(ω-alkenyl)-N-tosylamides. These compounds, in turn, were prepared from unsaturated alcohols through the Mitsunobu reaction. This methodology gives access to five- and six-membered ring compounds. Additionally, chiral phosphonates can be obtained easily. Organocatalysis and ring-closing metathesis enable a two-step synthesis of azaheterocyclic vinylphosphonates, giving access to five- and six-membered ring compounds. The required (ω-alkenyl) p-toluenesulfonamides were obtained through the Mitsunobu reaction, which allows the synthesis of chiral phosphonates. Copyright
