14467-49-3

Basic information

• Product Name: Benzenemethanol, a-[[(1-methylethyl)amino]methyl]-,(aR)-
• Synonyms: Benzenemethanol,a-[[(1-methylethyl)amino]methyl]-,(R)-; Benzyl alcohol, a-[(isopropylamino)methyl]-, D-(-)- (8CI); TV 695
• CAS NO: 14467-49-3
• Molecular Formula: C11H17 N O
• Molecular Weight: 179.262
• Mol File: 14467-49-3.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-[[(1-methylethyl)amino]methyl]-,(aR)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-[[(1-methylethyl)amino]methyl]-,(aR)-(14467-49-3)
• EPA Substance Registry System: Benzenemethanol, a-[[(1-methylethyl)amino]methyl]-,(aR)-(14467-49-3)

Safety Data

• Hazardous Substances Data: 14467-49-3(Hazardous Substances Data)

Upstream product

• 96-09-3 styrene oxide 
• 75-31-0 isopropylamine 
• 107-10-8 propylamine 
• 67-64-1 acetone 
• 7568-93-6 2-Amino-1-phenylethanol 
• 130614-76-5 N-isopropyl-O-acetylmandelamide 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 96-09-3 2‐phenyloxirane 
• 49845-69-4 (R)-O-acetylmandeloyl chloride 
• 71065-28-6 1R,2S,5R-(-)-8-phenylmenthyl mandelate 
• 10020-96-9 (R)-Mandelonitrile 
• 142429-13-8 (R)-(+)-<(2-methoxy-iso-propyl)oxy>benzeneacetonitrile 
• 91850-94-1 2-(isopropylimino)-1-phenylethanone 
• 89843-14-1 2-hydroxy-N-isopropyl-2-phenylacetamide 

Downstream Products

• 1078-35-9 N-(2-chloro-2-phenylethyl)isopropylammonium chloride 
• 4164-21-0 2-(isopropylamino)-1-phenylethanol 
• 1460197-46-9 N-(2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]oxy}-2-phenylethyl)propan-2-amine 
• 1415504-56-1 2-{[3-(1-benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl](isopropyl)amino}-1-phenylethanol 
• 2027-65-8 1-(1-methylethyl)-3-phenyl-2-azetidinone 
• 4164-23-2 1-isopropyl-2-phenyl-aziridine 
• 116203-87-3 N-nitroso-2-isopropylamino-1-phenylethanol 
• 25244-11-5 2-(isopropyl-methyl-amino)-1-phenyl-ethanol 

Relevant articles and documents

Efficient Synthesis of 2-Amino-1-Arylethanols Through a Lewis Base-Catalyzed SiCl4-Mediated Asymmetric Passerini-Type Reaction

We herein report, a practical and efficient strategy for the synthesis of enantiomerically enriched 2-amino-1-arylethanols, a structural motif commonly encountered in the family of β-adrenergic blockers or agonists, through a Lewis base-catalyzed SiClsub

2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.

Stereoselective synthesis of (1R)- and (1R,2S)-1-aryl-2-alkylamino alcohols from (R)-cyanohydrins

Hydrogenation of (R)-cyanohydrins (R)-1 with LiAlH4 occurs without racemization to give the (R)-2-amino alcohols (R)-3. (1R,2S)-2-Amino alcohols (1R,2S)-4 are obtained with high diastereoselectivity by addition of methyl Grignard to O-silyl protected cyanohydrins (R)-2 and subsequent hydrogenation with NaBH4. The N-alkylated 2-amino alcohols (R)-8 and (1R,2S)-9 can be prepared either by reductive alkylation of the corresponding 2-amino alcohols (R)-3 and (1R,2S)-4, respectively, or by a transimination reaction of the Grignard addition products with primary amines and subsequent hydrogenation with NaBH4. The lower diastereoselectivity of hydrogenation in case of the N-alkylmino compounds in comparison to the N-unsubstituted imines is explained by a weaker chelating effect.