144675-80-9

Basic information

• Product Name: Benzene, [[[1-(2-propenyl)-3-butenyl]oxy]methyl]-
• CAS NO: 144675-80-9
• Molecular Formula: C14H18O
• Molecular Weight: 202.296
• Mol File: 144675-80-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, [[[1-(2-propenyl)-3-butenyl]oxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [[[1-(2-propenyl)-3-butenyl]oxy]methyl]-(144675-80-9)
• EPA Substance Registry System: Benzene, [[[1-(2-propenyl)-3-butenyl]oxy]methyl]-(144675-80-9)

Safety Data

• Hazardous Substances Data: 144675-80-9(Hazardous Substances Data)

Upstream product

• 2883-45-6 1, 6-heptadien-4-ol 
• 100-39-0 benzyl bromide 

Downstream Products

• 2883-45-6 1, 6-heptadien-4-ol 
• 37005-79-1 [(cyclopent-3-en-1-yloxy)methyl]benzene 
• 1095550-09-6 C₁₂H₁₆O₃ 
• 1466415-66-6 4-(benzyloxy)heptane-1,7-diol 

Relevant articles and documents

Compounds and Their Use in Treating Cancer

The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts and prodrugs thereof, where R1, R4, R5, R6, R7, Linker, X, Y, A, G, D and E have any of the meanings defined herein. This specification also relates to the use of such compounds and pharmaceutically acceptable salts and prodrugs thereof in methods of treatment of the human or animal body, for example in prevention or treatment of cancer. This specification also relates to processes and intermediate compounds involved in the preparation of such compounds and to pharmaceutical compositions containing them.

Low catalyst loading in ring-closing metathesis reactions

An efficient procedure is described for ring-closing metathesis reactions. A conversion of 95 % for diethyl diallylmalonate in dilute solution could be achieved within a few minutes, reaching TOF=4173min-1, with very low loading of commercially available Ru catalysts that contained unsaturated NHC ligands. In general, only 50 to 250ppm of the catalyst is required to achieve near-quantitative conversion into a broad variety of 5-16-membered heterocyclic compounds. The practicality of this procedure was illustrated in the synthesis of 5-8-membered N-tert-butoxycarbonyl (N-Boc)- and N-para-toluenesulfonyl (N-Ts)-protected cyclic amines and 9-16-membered lactones. The synthesis of macrocyclic proline-based lactams required slightly higher catalyst loadings. Along with monocyclic products, oligomeric byproducts, mostly cyclodimers, were isolated and characterized. Getting some closure: An efficient procedure is described for ring-closing metathesis reactions in which only 50 to 250ppm of catalyst is required to effect almost-quantitative conversion into a broad range of 5-16-membered heterocyclic compounds. The practicality of this procedure was illustrated in the synthesis of 5-8-membered N-protected cyclic amines, 9-16-membered lactones, and 11-16-membered proline-based lactams. Copyright