1446863-07-5

Basic information

• Product Name: 2-(4-t-butylphenyl)-5-methylquinoxaline
• Synonyms: 2-(4-t-butylphenyl)-5-methylquinoxaline
• CAS NO: 1446863-07-5
• Molecular Weight: 276.381
• Mol File: 1446863-07-5.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-t-butylphenyl)-5-methylquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-t-butylphenyl)-5-methylquinoxaline(1446863-07-5)
• EPA Substance Registry System: 2-(4-t-butylphenyl)-5-methylquinoxaline(1446863-07-5)

Safety Data

• Hazardous Substances Data: 1446863-07-5(Hazardous Substances Data)

Upstream product

• 2687-25-4 3-methyl-1,2-benzenediamine 
• 61148-17-2 2-chloro-5-methylquinoxaline 
• 123324-71-0 p-tert-butylphenylboronic acid 

Downstream Products

• 1446863-11-1 di-N-Boc-1-((2-(4-t-butylphenyl)quinoxalin-5-yl)methyl)guanidine 
• 1446863-09-7 2-(4-t-butylphenyl)-5-(bromomethyl)quinoxaline 
• 1446862-63-0 1-((2-(4-t-butylphenyl)quinoxalin-5-yl)methyl)guanidine 

Relevant articles and documents

Antimicrobial agents

The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula I: wherein two of X1 to X8 are N and the remaining of X1 to X8 are CH; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof.

Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines

Several phenyl substituted naphthalenes and isoquinolines have been identified as antibacterial agents that inhibit FtsZ-Zing formation. In the present study we evaluated the antibacterial of several phenyl substituted quinoxalines, quinazolines and 1,5-naphthyridines against methicillin-sensitive and methicillin-resistant Staphylococcus aureus and vancomycin-sensitive and vancomycin-resistant Enterococcus faecalis. Some of the more active compounds against S. aureus were evaluated for their effect on FtsZ protein polymerization. Further studies were also performed to assess their relative bactericidal and bacteriostatic activities. The notable differences observed between nonquaternized and quaternized quinoxaline derivatives suggest that differing mechanisms of action are associated with their antibacterial properties.

ANTIMICROBIAL AGENTS

The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula I: wherein two of X1 to X8 are N and the remaining of X1 to X8 are CH; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof.