1447047-26-8

Basic information

• Product Name: C₃₅H₅₄N₆O₉
• Synonyms: C₃₅H₅₄N₆O₉
• CAS NO: 1447047-26-8
• Molecular Weight: 702.849
• Mol File: 1447047-26-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₅H₅₄N₆O₉(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₅H₅₄N₆O₉(1447047-26-8)
• EPA Substance Registry System: C₃₅H₅₄N₆O₉(1447047-26-8)

Safety Data

• Hazardous Substances Data: 1447047-26-8(Hazardous Substances Data)

Upstream product

• 869116-13-2 Cbz-L-propargylglycine-OH 
• 21691-53-2 L-leucine tert-butyl ester 
• 1447047-24-6 C₂₃H₃₂N₂O₅ 
• 468065-37-4 methyl 6-azido-2-(boc-amino)hexanoate 

Downstream Products

• 1447047-28-0 C₂₆H₃₈N₆O₇ 
• 1417159-36-4 methyl (6S,9S,12S)-12-(((benzyloxy)carbonyl)amino)-9-isobutyl-8,11-dioxo-1,7,10,15,16-pentaazabicyclo[12.2.1]heptadeca-14⁽¹⁷⁾,15-diene-6-carboxylate 
• 1417159-37-5 benzyl ((6S,9S,12S)-6-(hydroxymethyl)-9-isobutyl-8,11-dioxo-1,7,10,15,16-pentaazabicyclo[12.2.1]heptadeca-14⁽¹⁷⁾,15-dien-12-yl)carbamate 
• 1417159-38-6 benzyl ((6S,9S,12S)-6-formyl-9-isobutyl-8,11-dioxo-1,7,10,15,16-pentaazabicyclo[12.2.1]heptadeca-14⁽¹⁷⁾,15-dien-12-yl)carbamate 

Relevant articles and documents

Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors

Peptide-derived protease inhibitors are an important class of compounds with the potential to treat a wide range of diseases. Herein, we describe the synthesis of a series of triazole- containing macrocyclic protease inhibitors pre-organized into a b-strand conformation and an evaluation of their activity against a panel of proteases. Acyclic azidoalkyne-based aldehydes are also evaluated for comparison. The macrocyclic peptidomimetics showed considerable activity towards calpain II, cathepsin L and S, and the 20S proteasome chymotrypsin-like activity. Some of the first examples of highly potent macrocyclic inhibitors of cathepsin S were identified. These adopt a well-defined b-strand geometry as shown by NMR spectroscopy, X-ray analysis, and molecular docking studies.