21691-53-2

Basic information

• Product Name: L-LEUCINE TERT-BUTYL ESTER HYDROCHLORIDE
• Synonyms: Leucine tert-butyl ester;L-Leucine tert-butyl;L-Leucine tert-butyl ester
• CAS NO: 21691-53-2
• Molecular Formula: C₁₀H₂₁NO₂
• Molecular Weight: 223.74
• Mol File: 21691-53-2.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: L-LEUCINE TERT-BUTYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: L-LEUCINE TERT-BUTYL ESTER HYDROCHLORIDE(21691-53-2)
• EPA Substance Registry System: L-LEUCINE TERT-BUTYL ESTER HYDROCHLORIDE(21691-53-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 21691-53-2(Hazardous Substances Data)

Usage

General Description

L-Leucine tert-butyl ester hydrochloride is a chemical compound that is a derivative of the amino acid L-leucine. It is commonly used in organic synthesis as a reagent for the protection of the amino group in peptide synthesis. L-LEUCINE TERT-BUTYL ESTER HYDROCHLORIDE is important in the pharmaceutical industry for the production of various drugs and medications. It is also used in research and development for the synthesis of peptides and other organic compounds. L-Leucine tert-butyl ester hydrochloride is a stable and versatile compound that is essential in the field of organic chemistry.

Upstream product

• 61-90-5 L-leucine 
• 115-11-7 isobutene 
• 2018-66-8 Z-Leu-OH 
• 75-65-0 tert-butyl alcohol 
• 75716-87-9 tert-butyl 4-methyl-2-oxopentanoate 
• 2748-02-9 L-leucine tert-butyl ester hydrochloride 
• 1245735-67-4 Fms-Leu-OtBu 
• 327026-68-6 Psoc-Leu-OtBu 
• 16881-37-1 (S)-tert-butyl 2-(benzyloxycarbonylamino)-4-methylpentanoate 
• 64-19-7 acetic acid 
• 540-88-5 acetic acid tert-butyl ester 

Downstream Products

• 80870-32-2 N-benzylidene<(S)-1-t-butoxycarbonyl-3-methyl>butylamine 
• 52616-98-5 Cbz-Val-Leu-OtBu 
• 1166862-14-1 C₁₉H₃₁NO₄ 
• 1252060-51-7 tert-butyl N-(4-iodobenzyl)-L-leucinate 
• 1259946-56-9 N-(benzylcarbamoyl)-leucine 1,2-dimethylhydrazide 
• 1259946-59-2 (N-phenylcarbamoyl)leucine 1,2-dimethylhydrazide 
• 1259947-27-7 C₁₉H₃₀N₄O₄ 
• 1259946-84-3 N-[4-(5-methyl-1,2,4-oxadiazol-3-yl)benzylcarbamoyl]leucine 1,2-dimethylhydrazide 

Relevant articles and documents

Synthesis of malformin-A1, C, a glycan, and an aglycon analog: Potential scaffolds for targeted cancer therapy

Improvement in therapeutic efficacy while reducing chemotherapeutic side effects remains a vital objective in synthetic design for cancer treatment. In keeping with the ethos of therapeutic development and inspired by the Warburg effect for augmenting biological activities of the malformin family of cyclic-peptide natural products, specifically anti-tumor activity, a β-glucoside of malformin C has been designed and synthesized utilizing precise glycosylation and solution phase peptide synthesis. We optimized several glycosylation procedures utilizing different donors and acceptors. The overarching goal of this study was to ensure a targeted delivery of a glyco-malformin C analog through the coupling of D-glucose moiety; selective transport via glucose transporters (GLUTs) into tumor cells, followed by hydrolysis in the tumor microenvironment releasing the active malformin C a glycon analog. Furthermore, total synthesis of malformin C was carried out with overall improved strategies avoiding unwanted side reactions thus increasing easier purification. We also report on an improved solid phase peptide synthesis protocol for malformin A1.

Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids

We report herein a Pd(II)/bis-sulfoxide-catalyzed intramolecular allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramolecular carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity.

Asymmetric Synthesis of α-Amino Acids by Organocatalytic Biomimetic Transamination

A biomimetic enantioselective transamination of α-keto ester derivatives can be realized under mild conditions by using chiral quaternary ammonium arenecarboxylates in the absence of base additives. The corresponding α-amino acids can be used as versatile intermediates for further synthetic transformations that furnish chiral pyrrolidine and octahydroindolizine derivatives.