144709-18-2

Upstream product

• 144709-15-9 [4,5-Dimethoxy-2-(1-oxo-1,2-dihydro-isoquinolin-3-yl)-phenyl]-acetic acid 
• 144709-27-3 3-<2-(methoxycarbonylmethyl)-4,5-dimethoxyphenyl>-1(2H)-isoquinolone 
• 74-88-4 methyl iodide 

Downstream Products

• 144709-19-3 N-methyl-3-<2-hydroxyethyl-4,5-dimethoxyphenyl>-1(2H)-isoquinolone 

Relevant academic research and scientific papers

A common and general access to berberine and benzo [c] phenanthridine alkaloids

The S(RN)1 reactions between o-iodobenzamides and the enolate anion from 2-acetyl homoveratric acid lead to key tricyclic compounds which are easily converted to either berberine or benzo [c] phenanthridine ring systems providing thus a highly-yielding and versatile access to both classes of alkaloids.