144709-20-6

Basic information

• Product Name: Benzamide, 2-iodo-4,5-dimethoxy-
• Synonyms: 2-Iodo-4,5-dimethoxy-benzamide
• CAS NO: 144709-20-6
• Molecular Formula: C9H10INO3
• Molecular Weight: 307.08500
• Mol File: 144709-20-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-iodo-4,5-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-iodo-4,5-dimethoxy-(144709-20-6)
• EPA Substance Registry System: Benzamide, 2-iodo-4,5-dimethoxy-(144709-20-6)

Safety Data

• Hazardous Substances Data: 144709-20-6(Hazardous Substances Data)

Upstream product

• 61203-48-3 2-iodo-4,5-dimethoxybenzoic acid 

Downstream Products

• 144709-21-7 [2-(6,7-Dimethoxy-1-oxo-1,2-dihydro-isoquinolin-3-yl)-4,5-dimethoxy-phenyl]-acetic acid 
• 53948-09-7 aristololactam BII 
• 144709-24-0 N-methyl-3<2-(methoxycarbonylmethyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-1(2H)-isoquinolone 
• 144709-22-8 3-<2-(methoxycarbonyl-methyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-1(2H)-isoquinolone 
• 144709-25-1 3<2-(methoxycarbonylmethyl)-4,5-dimethoxyphenyl>1,6,7-trimethoxy-isoquinoline 
• 144709-23-9 3-<2-(hydroxyethyl)-4,5-dimethoxyphenyl>6,7-dimethoxy-1(2H)-isoquinolone 
• 136540-25-5 3-<2-(2-hydroxyethyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-2-methylisoquinolin-1-<2H>-one 

Relevant articles and documents

Phosphazene Superbase-Mediated Regio- and Stereoselective Iodoaminocyclization of 2-(1-Alkynyl)benzamides for the Synthesis of Isoindolin-1-ones

Phosphazene superbase P4-t-Bu mediated iodoaminocyclization of 2-(1-alkynyl)benzamides is reported. The reaction works under ambient conditions and instantaneously results in the synthesis of isoindolin-1-ones in 65-97% yields, in a regio- and stereoselective manner. The exclusive formation of products with Z-geometry (across the exo C?C bond) has been confirmed through X-ray crystallography. The methodology also provides an easy access to aristolactams, an important class of natural products. This has been successfully demonstrated by synthesizing two aristolactam derivatives (including Cepharanone B).