144710-35-0

Upstream product

• 7697-46-3 phenyl(1H-pyrrol-2-yl)methanone 
• 685-87-0 Diethyl 2-bromomalonate 
• 218966-77-9 S-diethoxycarbonylmethyl O-ethyl dithiocarbonate 
• 105-53-3 diethyl malonate 
• 14064-10-9 diethyl 2-chloromalonate 
• 144710-34-9 diethyl 5-benzoylpyrrol-2-yl-(α-acetoxy)malonate 
• 136116-84-2 triethyl (5-benzoylpyrrol-2-yl)-methanetricarboxylate 

Downstream Products

• 140947-23-5 diethyl 5-benzoyl-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1,1-dicarboxylate 
• 1257530-78-1 diethyl 3-benzoyl-7,8-dihydro-5H-pyrrolo[1,2-a]azepine-9,9(6H)-dicarboxylate 
• 1257530-75-8 diethyl 3-benzoyl-6,7-dihydroindolizine-8,8(5H)-dicarboxylate 
• 74103-06-3 Ketorolac 

Relevant academic research and scientific papers

Solvent free oxidative radical substitution process. Synthesis of pyrrole fused systems

A xanthate-based, solvent free, homolytic substitution on selected substituted pyrrole systems is described. Additionally, a practical entry for the rapid construction of pyrrole fused systems using this solventless radical addition followed by a double nucleophilic alkylation sequence, is also reported.

Process for preparing pyrrolizine derivatives

This invention relates to novel processes for preparing substituted pyrrolizine compounds. More particularly, it relates to novel processes for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylate of the following formula (I) from pyrrole. STR1

Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (II) and intermediates therefor

5-Aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates of the formula STR1 are prepared from 2-aroylpyrroles. Hydrolysis and mono-decarboxylation of these compounds affords ketorolac and related compounds.