144729-95-3Relevant academic research and scientific papers
Cooperative titanocene and phosphine catalysis: Accelerated C-X activation for the generation of reactive organometallics
Fleury, Lauren M.,Kosal, Andrew D.,Masters, James T.,Ashfeld, Brandon L.
, p. 253 - 269 (2013/03/14)
The study presented herein describes a reductive transmetalation approach toward the generation of Grignard and organozinc reagents mediated by a titanocene catalyst. This method enables the metalation of functionalized substrates without loss of functional group compatibility. Allyl zinc reagents and allyl, vinyl, and alkyl Grignard reagents were generated in situ and used in the addition to carbonyl substrates to provide the corresponding carbinols in yields up to 99%. It was discovered that phosphine ligands effectively accelerate the reductive transmetalation event to enable the metalation of C-X bonds at temperatures as low as -40 °C. Performing the reactions in the presence of chiral diamines and amino alcohols led to the enantioselective allylation of aldehydes.
Synthesis and Reactions of 2-Cyclopropyl-2-propenyltrimethylsilane. Silicon-Directed Generation of Cyclopropylcarbinyl System
Hojo, Makoto,Ohsumi, Katsufumi,Hosomi, Akira
, p. 5981 - 5982 (2007/10/02)
2-Cyclopropyl-2-propenyltrimethylsilane reacts with various kinds of carbon electrophiles to afford the corresponding allylation products without contamination of other products based on the rearrangement of a cyclopropyl ring.
