1447346-44-2Relevant academic research and scientific papers
Stereoselective synthesis of 2,5-disubstituted morpholines using a palladium-catalyzed hydroamination reaction
McGhee, Alicia,Cochran, Brian M.,Stenmark, Torrey A.,Michael, Forrest E.
, p. 6800 - 6802 (2013/07/26)
A palladium-catalyzed hydroamination reaction is the key step in a stereoselective synthesis of 2,5-disubstituted and 2,3,5-trisubsituted morpholines from carbamate-protected aziridines. Aziridines are selectively attacked at the more substituted position by unsaturated alcohol nucleophiles using Lewis acid catalysts. Palladium-catalyzed hydroamination of the resulting aminoalkenes gives morpholines as a single diastereomer in excellent yield.
