25711-25-5

Upstream product

• 93407-96-6 2-(((benzyloxy)carbonyl)amino)ethyl 4-methylbenzenesulfonate 
• 77987-49-6 benzyl 2-hydroxyethylcarbamate 
• 151-56-4 ethyleneimine 
• 501-53-1 benzyl chloroformate 
• 671-51-2 N-ethoxycarbonylaziridine 
• 15205-57-9 tribenzyl phosphite 

Downstream Products

• 147688-17-3 16-Benzyloxycarbonylaminoethylene-1,4,7,10,13-pentaoxa-16-azacyclooctadecane 
• 147688-22-0 3,12-Dibenzyl-1,14-bis(benzyloxycarbonylamino)-6,9-dioxa-3,12-diazatetradecane 
• 147688-19-5 7,16-Bis(benzyloxycarbonylaminoethylene)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane 
• 1039756-05-2 ethyl 4-(((benzyloxy)carbonyl)amino)-2-cyano-2-phenylbutanoate 
• 1215528-41-8 benzyl 3-methylmorpholine-4-carboxylate 
• 1447346-44-2 C₁₃H₁₇NO₃ 
• 1001404-36-9 H(8O₂,2)-CBZ 
• 1028803-13-5 C₅₁H₆₉N₇O₁₀ 
• 1180001-37-9 benzyl oct-3-ynylcarbamate 
• 908332-43-4 tert-butyl 2-(2-{[(benzyloxy)carbonyl]amino}ethyl)-5-biphenyl-4-yl-3-oxopentanoate 
• 147688-26-4 3,9-Dibenzyl-1,11-bis(benzyloxycarbonylamino)-6-oxa-3,9-diazaundecane-4,8-dione 
• 147688-15-1 13-Benzyloxycarbonylaminoethylen-1,4,7,10-tetraoxa-13-azacyclopentadecane 

Relevant academic research and scientific papers

CONJUGATED CHEMICAL INDUCERS OF DEGRADATION AND METHODS OF USE

The subject matter described herein is directed to antibody-CIDE conjugates (Ab-CIDEs), to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where targeted protein degradation is beneficial.

Barium complexes with crown-ether-functionalised amidinate and iminoanilide ligands for the hydrophosphination of vinylarenes

The detailed multistep syntheses of two nitrogen-based sterically congested iminoanilidine and amidine proligands bearing a tethered 15-member aza-ether-crown macrocycle, namely {I^Acrown}H and {Amcrown}H, are reported. These proligands react with [Ba{N(SiMe2H)2}2·(thf)n] to generate the heteroleptic barium complexes [{I^Acrown}BaN(SiMe2H)2] (5) and [{Amcrown}BaN(SiMe2H)2] (6) in high yields. These complexes exhibit high coordination numbers (resp. eight and seven) and are in addition stabilised by mild Ba?H-Si interactions. Unusually for oxophilic elements such as barium, the amidinate ligand in 6 is only η1-coordinated. Complexes 5 and 6 mediate the intermolecular hydrophosphination of styrene with primary (PhPH2) and secondary (HPPh2) phosphines. Their catalytic performance compares favourably with those of other barium precatalysts for these reactions. During the course of the hydrophosphination of styrene with HPPh2 catalysed by 5, the phosphide complex [{I^Acrown}BaPPh2] (7) could be intercepted and crystallographically characterised.

Modular One-Step Three-Component Synthesis of Tetrahydroisoquinolines Using a Catellani Strategy

Reported is a modular one-step three-component synthesis of tetrahydroisoquinolines using a Catellani strategy. This process exploits aziridines as the alkylating reagents, through palladium/norbornene cooperative catalysis, to enable a Catellani/Heck/aza-Michael addition cascade. This mild, chemoselective, and scalable protocol has broad substrate scope (43 examples, up to 90 % yield). The most striking feature of this protocol is the excellent regioselectivity and diastereoselectivity observed for 2-alkyl- and 2-aryl-substituted aziridines to access 1,3-cis-substituted and 1,4-cis-substituted tetrahydroisoquinolines, respectively. Moreover, this is a versatile process with high step and atom economy.

Eu(III) complexes of functionalized octadentate 1-hydroxypyridin-2-ones: Stability, bioconjugation, and luminescence resonance energy transfer studies

The synthesis, stability, and photophysical properties of several Eu(III) complexes featuring the 1-hydroxypyridin-2-one (1,2-HOPO) chelate group in tetradentate and octadentate ligands are reported. These complexes pair highly efficient emission with exc

LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES

The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

N-Benzyloxycarbonylaziridine in the Syntheses of 2-Aminoethyl Armed Lariats and Selectively N-Protected Polyazacrown Ethers

The 15- and 18-membered mono- and bi-bracchial N-aminoethylene armed lariats 6, 7 and 8 have been synthesized by alkylations of parent azacrowns using N-benzyloxycarbonylaziridine 2 and subsequent removal of Z-protecting groups by catalytic hydrogenolysis

REACTIONS WITH AZIRIDINES XXI. THE (MICHAELIS-)ARBUSOV REACTION WITH N-ACYL AZIRIDINES AND OTHER AMIDOETHYLATIONS AT PHOSPHORUS.

Heating trialkyl phosphites with N-acyl aziridines produces dialkyl 2-amidoethyl-phosphonates bearing one of the phosphite alkyl groups on nitrogen.Other alkoxy phosphines behave analogously.Dilakyl phophites furnish the same type of products devoid of the N-alkyl group.