1447464-22-3Relevant academic research and scientific papers
3-Aryl-3-arylmethoxyazetidines. A new class of high affinity ligands for monoamine transporters
Thaxton, Amber,Izenwasser, Sari,Wade, Dean,Stevens, Edwin D.,Mobley, David L.,Jaber, Vivian,Lomenzo, Stacey A.,Trudell, Mark L.
, p. 4404 - 4407 (2013/07/25)
A series of 3-aryl-3-arylmethoxy-azetidines were synthesized and evaluated for binding affinities at dopamine and serotonin transporters. The 3-aryl-3-arylmethoxyazetidines were generally SERT selective with the dichloro substituted congener 7c (Ki = 1.0 nM) and the tetrachloro substituted derivative 7i (Ki = 1.3 nM) possessing low nanomolar affinity for the SERT. The 3-(3,4-dichlorophenyl-3-phenylmethoxyazetidine (7g) exhibited moderate affinity at both DAT and SERT transporters and suggests that substitution of the aryl rings can be used to tune the mononamine transporter affinity.
