1447465-10-2Relevant academic research and scientific papers
Mono- and bis-alkylation of glyoxal-bridged tetraazamacrocycles using mechanochemistry
Abdulwahaab, Bassim H.,Burke, Benjamin P.,Domarkas, Juozas,Silversides, Jon D.,Prior, Timothy J.,Archibald, Stephen J.
, p. 890 - 898 (2016)
Glyoxal-bridged bisaminal tetraazamacrocyclic derivatives of 1,4,7,10-tetraazacyclododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) can be N-functionalized to incorporate coordinating groups or for conjugation to biomolecules. Herein, we p
Rapid synthesis of cross-bridged cyclam chelators for copper(II) complex formation
Silversides, Jon D.,Burke, Benjamin P.,Archibald, Stephen J.
, p. 524 - 530 (2013/07/26)
Copper(II) complexes of 1,4,8,11-tetraazabicyclo[6.6.2]hexadecane (cross-bridged cyclam) derived chelators show high kinetic stability relative to less rigid non-bridged azamacrocyclic chelators and have applications as radiopharmaceuticals in PET imaging. Rapid synthesis of two novel bis-benzyl cross-bridged cyclam derivatives was achieved in 24 h compared to the typical synthesis times, between 14 and 30 days. The X-ray crystal structures are reported for the copper(II) complexes with 1,3-dibromobenzyl and tolyl derivatives revealing different ligand coordination environments. Both structures show tetradentate coordination of the tetraazamacrocycle with axial elongation along the N-Cu-N axis for the 1,3-dibromobenzyl derivative (Cu-N distances: axial av. 2.48(8) ?, equatorial av. 2.081(7) ?).
