1447648-74-9

Basic information

• Product Name: 1-((1-(1H-indazol-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-3-(3,4-dimethoxyphenyl)urea
• Synonyms: 1-((1-(1H-indazol-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-3-(3,4-dimethoxyphenyl)urea
• CAS NO: 1447648-74-9
• Molecular Weight: 393.405
• Mol File: 1447648-74-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-((1-(1H-indazol-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-3-(3,4-dimethoxyphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((1-(1H-indazol-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-3-(3,4-dimethoxyphenyl)urea(1447648-74-9)
• EPA Substance Registry System: 1-((1-(1H-indazol-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-3-(3,4-dimethoxyphenyl)urea(1447648-74-9)

Safety Data

• Hazardous Substances Data: 1447648-74-9(Hazardous Substances Data)

Upstream product

• 37527-66-5 3,4-dimethoxyphenylisocyanate 
• 40926-90-7 3,4-dimethoxybenzoyl azide 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 19335-11-6 1H-indazol-5-ylamine 
• 20376-99-2 6-azido-1H-indazole 
• 1432579-07-1 1-(3,4-dimethoxyphenyl)-3-(2-propynyl)urea 

Relevant articles and documents

Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach

We report a novel VEGFR-2 inhibitor, developed by the back-to-front approach. Docking experiments indicated that the 3-chloromethylphenylurea motif of the lead compound occupied the back pocket of VEGFR-2 kinase. An attempt was made to enhance the binding affinity of 1 by expanding the structure to access the front pocket using a triazole linker. A library of 1,4-(disubstituted)-1H-1, 2,3-triazoles were screened in silico, and one compound (VH02) was identified with an IC50 against VEGFR-2 of 0.56 μM. VH02 showed antiangiogenic effects, inhibiting tube formation in HUVEC cells (EA.hy926) at 0.3 μM, 13 times lower than its cytotoxic dose. These enzymatic and cellular activities suggest that VH02 has potential as a lead for further optimization.