40926-90-7

Basic information

• Product Name: 3,4-dimethoxybenzoyl azide
• Synonyms: 3,4-dimethoxybenzoyl azide
• CAS NO: 40926-90-7
• Molecular Weight: 207.189
• Mol File: 40926-90-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3,4-dimethoxybenzoyl azide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dimethoxybenzoyl azide(40926-90-7)
• EPA Substance Registry System: 3,4-dimethoxybenzoyl azide(40926-90-7)

Safety Data

• Hazardous Substances Data: 40926-90-7(Hazardous Substances Data)

Upstream product

• 41764-74-3 3,4-dimethoxybenzohydrazide 
• 80370-28-1 1-(3,4-dimethoxy-phenyl)-3-(4-methoxy-phenyl)-propane-1,3-dione 
• 52751-63-0 1,3-di-(3,4-dimethoxyphenyl)-1,3-propanedione 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 93-07-2 Veratric acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 35162-34-6 N-methyl-3,4-dimethoxyaniline 
• 46809-30-7 3-(3,4-dimethoxy-phenyl)-1-methyl-imidazolidin-4-one 
• 1447648-74-9 1-((1-(1H-indazol-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-3-(3,4-dimethoxyphenyl)urea 
• 1432579-07-1 1-(3,4-dimethoxyphenyl)-3-(2-propynyl)urea 
• 37527-66-5 3,4-dimethoxyphenylisocyanate 

Relevant articles and documents

Synthesis of: N -methylated amines from acyl azides using methanol

The transformation of acyl azide derivatives into N-methylamines was developed using methanol as the C1 source via the one-pot Curtius rearrangement and borrowing hydrogen methodology. Following this protocol, various functionalised N-methylated amines were synthesized using the (NNN)Ru(ii) complex from carboxylic acids via an acyl azide intermediate. Several kinetic studies and DFT calculations were carried out to support the mechanism and also to determine the role of the Ru(ii) complex and base in this transformation.

Synthesis of Acyl Azides from 1,3-Diketones via Oxidative Cleavage of Two C-C Bonds

A metal-free PhI(OAc)2-mediated method for the synthesis of acyl azides through oxidative cleavage of 1,3-diketones is described. This method is shown to have a broad substrate scope, providing a useful tool for multiproduct synthesis in a single procedure. A possible reaction pathway is proposed based on mechanistic studies.

Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach

We report a novel VEGFR-2 inhibitor, developed by the back-to-front approach. Docking experiments indicated that the 3-chloromethylphenylurea motif of the lead compound occupied the back pocket of VEGFR-2 kinase. An attempt was made to enhance the binding affinity of 1 by expanding the structure to access the front pocket using a triazole linker. A library of 1,4-(disubstituted)-1H-1, 2,3-triazoles were screened in silico, and one compound (VH02) was identified with an IC50 against VEGFR-2 of 0.56 μM. VH02 showed antiangiogenic effects, inhibiting tube formation in HUVEC cells (EA.hy926) at 0.3 μM, 13 times lower than its cytotoxic dose. These enzymatic and cellular activities suggest that VH02 has potential as a lead for further optimization.