144766-10-9

Upstream product

• 144735-39-7 (2S)-2-<(R)-1-(dimethoxymethyl)-1-hydroxyethyl>pyrrolidine 
• 144735-38-6 (2S)-2-<(R)-1-(1,3-dithian-2-yl)-1-hydroxyethyl>pyrrolidine 
• 153108-84-0 (2S)-N-(cyanomethyl)-2-<(R)-1-(dimethoxymethyl)-1-hydroxyethyl>pyrrolidine 
• 153108-85-1 (2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>pyrrolidine 
• 144735-49-9 (2E,6E)-(4R,8R,9R)-2-iodo-8,9-(isopropylidenedioxy)-4,7-dimethyl-2,6-decadien-1-ol 
• 144735-50-2 (2E,6E)-(4R,8R,9R)-1-bromo-2-iodo-8,9-(isopropylidenedioxy)-4,7-dimethyl-2,6-decadiene 
• 144735-43-3 (2S)-2-<(R)-1-(benzyloxy)-1-<(tert-butyldimethylsiloxy)methyl>ethyl>pyrrolidine 
• 144735-40-0 (2S)-2-<(R)-1-(benzyloxy)-1-(dimethoxymethyl)ethyl>-N-(cyanomethyl)pyrrolidine 
• 144735-42-2 (2S)-N-<(benzyloxy)carbonyl>-2-<(R)-1-(benzyloxy)-1-(hydroxymethyl)ethyl>pyrrolidine 
• 153108-94-2 (2S)-2-<(R)-1-(benzyloxy)-1-<(tert-butyldimethylsiloxy)methyl>ethyl>-N-<(benzyloxy)carbonyl>pyrrolidine 
• 153108-95-3 (2S)-2-<(R)-1-(benzyloxy)-1-(hydroxymethyl)ethyl>-N-<(2E,6E)-(4R,8R,9R)-8,9-(isopropylidenedioxy)-4,7-dimethyl-2,6-decadien-1-yl>pyrrolidine 
• 144735-51-3 (2S)-2-<(R)-1-(benzyloxy)-1-<(tert-butyldimethylsiloxy)methyl>ethyl>-N-<(2E,6E)-(4R,8R,9R)-8,9-(isopropylidenedioxy)-4,7-dimethyl-2,6-decadien-1-yl>pyrrolidine 
• 144788-86-3 ethyl (E)-(4R,5R)-4,5-(isopropylidenedioxy)-3-methyl-2-hexenoate 
• 144735-45-5 (4S)-4-isopropyl-3-<(E)-(2R,6R,7R)-6,7-(isopropylidenedioxy)-2,5-dimethyl-4-octenoyl>-2-oxazolidinone 

Downstream Products

• 91550-04-8 (+)-Allopumiliotoxin 339B 
• 289659-71-8 (7S,8R,8aS)-8-Benzyloxy-8-methyl-6-[(E)-(R)-2-methyl-5-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-hex-4-en-(E)-ylidene]-octahydro-indolizin-7-ol 
• 289659-77-4 (E)-(2R,3R,7R)-8-[(7S,8R,8aS)-8-Benzyloxy-7-hydroxy-8-methyl-hexahydro-indolizin-(6E)-ylidene]-4,7-dimethyl-oct-4-ene-2,3-diol 
• 289659-70-7 (8R,8aS)-8-Benzyloxy-8-methyl-6-[(E)-(R)-2-methyl-5-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-hex-4-en-(E)-ylidene]-hexahydro-indolizin-7-one 
• 153108-96-4 (7R,8R,8aS)-8-(benzyloxy)-7-hydroxy-8-methyl-6-(E)-<(2R,6R,7R)-6,7-dihydroxy-2,5-dimethyl-4-(E)-octenylidene>octahydroindolizidine 

Relevant academic research and scientific papers

Nickel-catalyzed preparation of bicyclic heterocycles: Total synthesis of (+)-allopumiliotoxin 267A, (+)-allopumiliotoxin 339A, and (+)-allopumiliotoxin 339B

A new method for the reductive cyclization of ynals involving a Ni(COD)2/PBu3 catalyst system to produce allylic alcohols was developed. The triethylsilane-mediated procedure allows preparation of functionally rich pyrrolizidine, ind

Highly stereoselective total syntheses of (+)-allopumiliotoxins 267A and 339A via intramolecular nickel(II)/chromium(II)-mediated cyclization

Remarkably high regio- and stereoselective approaches for the syntheses of dendrobatid alkaloids (+)allopumiliotoxin 267A and 339A have been develop. As a model study for these alkaloids, we initially undertook intramolecular chromium(II)-mediated cycliza