1447666-75-2Relevant academic research and scientific papers
Gold-Catalyzed Regiospecific Hydration of N-Tosyl Propargylic Amines
Ying, Jun,Wang, Hai,Qi, Xinxin,Peng, Jin-Bao,Wu, Xiao-Feng
, p. 2837 - 2841 (2018/09/12)
A gold-catalyzed regiospecific hydration of N-tosyl propargylic amines has been developed. In the presence of a catalytic amount of the gold catalyst NaAuCl4·2H2O, both alkyl and aryl-substituted N-tosyl propargylic amines were smoothly converted into the corresponding β-amino ketones with excellent regioselectivities and high yields (up to 85%). Further transformations of the obtained β-amino ketones to valuable 1,3-amino alcohols were demonstrated as well.
Molecular sieve mediated decarboxylative Mannich and aldol reactions of β-ketoacids
Zhong, Fangrui,Jiang, Chunhui,Yao, Weijun,Xu, Li-Wen,Lu, Yixin
supporting information, p. 4333 - 4336 (2013/07/26)
A molecular sieve mediated decarboxylative Mannich reaction of β-ketoacids with sulfonyl imines is reported; this protocol leads to an efficient preparation of synthetically useful β-amino ketones. An analogous molecular sieve promoted decarboxylative aldol reaction between β-ketoacids and isatins is also described, which affords bioactive 3-substituted-3-hydroxy-oxindoles in excellent yields.
