1447670-81-6Relevant articles and documents
Edaravone cocrystals: Synthesis, screening, and preliminary characterization
Veverka, Miroslav,Dubaj, Tibor,Gallovic, Jan,Svajdlenka, Emil,Meaeuchova, Beata,Jorik, Vladimir,Simon, Peter
, p. 1335 - 1349 (2013)
Cocrystals constructed of edaravone (a neuroprotective agent) and phenolic acids (phytochemicals) are investigated. Edaravone and cocrystal formers were coground, slurried, and cocrystallized from solvent at 1:1, 2:1, and 1:2 molar ratios. The physicochemical characteristics of the products were studied using elemental analysis, optical microscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray powder diffraction. Edaravone cocrystals were prepared at various molar ratios. For three cocrystals, i.e., edaravone:gallic acid (2:1), edaravone:protocatechuic acid (1:1), and edaravone:trimesic acid (1:1), two polymorphs have been identified. Representative samples of the cocrystals were exposed to accelerated oxidative and thermal stress to investigate their stability. From the stability screening, protocatechuic acid and gallic acid cocrystals were identified as development candidates because they provide stable cocrystal forms.
