1447729-95-4Relevant academic research and scientific papers
Synthesis of 2-(fluorinated aryl)pyridine derivatives via palladium-catalyzed C–H bond arylation of fluorobenzenes using 2-halopyridines as aryl sources
Boyaala, Rabab,Touzani, Rachid,Guerchais, Véronique,Soulé, Jean-Fran?ois,Doucet, Henri
, p. 3205 - 3208 (2017)
We report herein on palladium-catalyzed direct arylation of (poly)fluorobenzene derivatives in the presence of 2-halopyridines for the one-step synthesis of 2-[(poly)fluorinated aryl]pyridine derivatives. The reactivity of 2-bromopyridines strongly dependents on its substituents at C6 position. The reaction proceeds nicely using a diphosphine palladium catalyst, and potassium pivalate/dimethylacetamide (PivOK/DMA) as catalytic system. The reaction was regioselective and occurred at the ortho-position of fluorine atoms.
Fluorine-containing aromatic derivatives of selective hydrogenation reduction method
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Paragraph 0151; 0152; 0153; 0154, (2017/11/27)
The invention discloses a selective hydrogenation reduction method of a fluorine-containing aromatic hydrocarbon derivative, and particularly discloses a preparation method of a compound shown in a general formula C1, C2 or C3. The preparation method comprises the following step of: reacting a compound shown in a general formula A1, A2 or A3 with a compound shown in a general formula B in the presence of a catalyst, thus forming the compound shown in the general formula C1, C2 or C3.
Method used for synthesizing heterocycle substituted multi-fluoro arene through defluorination and hydrogenation and controlled by phosphine ligand
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Paragraph 0049; 0050, (2016/12/16)
The invention discloses a method for synthesizing heterocycle substituted multi-fluoro arene through defluorination and hydrogenation and controlled by a phosphine ligand, and belongs to the technical field of chemical engineering. Cheap heterocycle subst
Palladium-catalyzed ortho-selective c-f activation of polyfluoroarenes with triethylsilane: A facile access to partially fluorinated aromatics
Chen, Zhao,He, Chun-Yang,Yin, Zengsheng,Chen, Liye,He, Yi,Zhang, Xingang
supporting information, p. 5813 - 5817 (2013/07/11)
PdF: A simple catalytic system, broad substrate scope, and high versatility provide a useful and facile access to partially fluorinated aromatics (see scheme). Tuning the reaction conditions enables a diverse range of product structures to be prepared. Copyright
