89562-59-4Relevant academic research and scientific papers
Transition-Metal-Free Desulfinative Cross-Coupling of Heteroaryl Sulfinates with Grignard Reagents
Wei, Jun,Liang, Huamin,Ni, Chuanfa,Sheng, Rong,Hu, Jinbo
supporting information, (2019/02/05)
A mild cross-coupling reaction of heteroaryl sulfinates with Grignard reagents has been developed under transition-metal-free conditions. This study provides an example of the SO22- as a leaving group in an aromatic system and an effective methodology for the construction of C-C bond.
Direct C-Li/C-H coupling of pentafluorophenyl lithium with azines - An atom- and step-economical strategy for the synthesis of polyfluoroaryl azaaromatics
Varaksin, Mikhail V.,Moseev, Timofey D.,Charushin, Valery N.,Chupakhin, Oleg N.
, p. 278 - 283 (2018/02/06)
The SNH methodology has successfully been applied for the direct C(sp2)-H functionalization of azaaromatics through the C-Li/C-H coupling of pentafluorophenyl lithium with azines and their N-oxides. As a result, a number of novel fluorinated biheterocyclic ensembles, that are of interest in the design of bioactive molecules and advanced materials, have been prepared in good to excellent yields under rather mild condition.
A general direct arylation of polyfluoroarenes with heteroaryl and aryl chlorides catalyzed by palladium indolylphosphine complexes
Yuen, On Ying,Charoensak, Mueangkaew,So, Chau Ming,Kuhakarn, Chutima,Kwong, Fuk Yee
supporting information, p. 857 - 861 (2015/03/31)
The first general examples of direct coupling of heteroaryl chlorides, especially substituted 2-pyridyl chlorides which were previously found to be problematic, with electron-deficient polyfluoroarenes are reported. Pd(OAc)2 associated with 3-(
Pd-catalyzed direct cross-coupling of electron-deficient polyfluoroarenes with heteroaromatic tosylates
Fan, Shilu,Yang, Jie,Zhang, Xingang
supporting information; experimental part, p. 4374 - 4377 (2011/10/08)
We report a Pd-catalyzed direct cross-coupling of electron-deficient polyfluoroarenes with heteroaromatic tosylates. The notable features of this reaction are its high reaction efficiency, excellent chemoselectivity, operational simplicity, and mild react
COPPER-CATALYZED C-H BOND ARYLATION
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Page/Page column 24, (2009/04/24)
The present invention is a one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using a combination of aryl halides, a substrate, and a copper salt as catalyst. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores and explosives.
A general method for copper-catalyzed arylation of arene C-H bonds
Do, Hien-Quang,Khan, Rana M. Kashif,Daugulis, Olafs
supporting information; experimental part, p. 15185 - 15192 (2009/03/12)
A general method for copper-catalyzed arylation of sp2 C-H bonds with pKa's below 35 has been developed. The method employs aryl halide as the coupling partner, lithium alkoxide or K3PO4 base, and DMF, DMPU, or mixed DMF/xylenes solvent. A variety of electron-rich and electron-poor heterocycles such as azoles, caffeine, thiophenes, benzofuran, pyridine oxides, pyridazine, and pyrimidine can be arylated. Furthermore, electron-poor arenes possessing at least two electron-withdrawing groups on a benzene ring can also be arylated. Two arylcopper-phenanthroline complex intermediates were independently synthesized.
