1447732-00-4Relevant articles and documents
Stereoselective synthesis of the C13-32 spiroacetal fragment of spirangien A
Gregg, Claire,Perkins, Michael V.
, p. 6845 - 6854 (2013/07/26)
Stereoselective synthesis of an advanced intermediate towards the highly cytotoxic polyketide metabolite spirangien A was achieved. A key step in the synthesis was installation of the C23 stereocentre by a substrate controlled C22-23 aldol reaction. Compa
Electrocyclization of oxatrienes in the construction of structurally complex pyranopyridones
Fotiadou, Anna D.,Zografos, Alexandros L.
supporting information, p. 5664 - 5667 (2013/01/15)
Application of a tandem Knoevenagel/6π-electrocyclization sequence is able to produce highly substituted pyranopyridones from moderate to high yields in a one-step reaction. High diasteroselectivity is observed in some cases and was rationalized on the basis of the thermodynamic control of the evidenced reversibility of a 6π-electrocyclization reaction. Numerous examples are provided establishing a novel entry in natural product-like structures of pyranopyridone alkaloids.