1447732-00-4

Upstream product

• 1447731-99-8 (2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 603121-10-4 (2S,4E)-2,4-dimethyl-4-hexenal 
• 101711-78-8 (3R)-3-propionyl-4-benzyloxazolidin-2-one 

Downstream Products

• 936946-36-0 (2'S,3'R,4'R,5'S,6'S,8E,4S)-3-[(5-[tert-butyldimethylsilyloxy]-3-triethylsilyloxyl-2,4,6,8-tetramethyl-1-oxo-dec-8-enyl)-4-(phenylmethyl)]-2-oxazolidinone 
• 936946-38-2 (2'S,3'R,4'S,5'S,6'S,8E,4S)-3-[(5-[tert-butyldimethylsilyloxy]-3-hydroxyl-2,4,6,8-tetramethyl-1-oxo-dec-8-enyl)-4-(phenylmethyl)]-2-oxazolidinone 

Relevant academic research and scientific papers

Stereoselective synthesis of the C13-32 spiroacetal fragment of spirangien A

Stereoselective synthesis of an advanced intermediate towards the highly cytotoxic polyketide metabolite spirangien A was achieved. A key step in the synthesis was installation of the C23 stereocentre by a substrate controlled C22-23 aldol reaction. Compa

Electrocyclization of oxatrienes in the construction of structurally complex pyranopyridones

Application of a tandem Knoevenagel/6π-electrocyclization sequence is able to produce highly substituted pyranopyridones from moderate to high yields in a one-step reaction. High diasteroselectivity is observed in some cases and was rationalized on the basis of the thermodynamic control of the evidenced reversibility of a 6π-electrocyclization reaction. Numerous examples are provided establishing a novel entry in natural product-like structures of pyranopyridone alkaloids.