936946-38-2

Upstream product

• 497-02-9 (E)-2-methyl-2-buten-1-ol 
• 1447732-00-4 (2'R,3'S,4'S,6E,4R)-3-[(3-[tert-butyldimethylsilyloxy]-2,4,6-trimethyl-1-oxo-oct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone 
• 159254-36-1 (2R)-(E)-2,4-dimethyl-4-hexenal 
• 1447732-01-5 (2R,3S,4S,6E)-3-(tert-butyldimethylsilyloxy)-2,4,6-trimethyl-oct-6-enal 
• 131685-53-5 (S)-4-benzyl-3-propionyl-2-oxazolidinone 
• 1447731-99-8 (2'R,3'S,4R,4'S,6E)-3-[(3-hydroxy-2,4,6-trimethyl-1-oxooct-6-enyl)-4-(phenylmethyl)]-2-oxazolidinone 
• 603121-10-4 (2S,4E)-2,4-dimethyl-4-hexenal 
• 57253-30-2 tiglyl bromide 
• 80-59-1 Tiglic acid 
• 936946-32-6 (R)-4-benzyl-3-((S,E)-2,4-dimethylhex-4-enoyl)oxazolidin-2-one 
• 936946-35-9 (2S,3S,4S,6E)-3-(tert-butyldimethylsilyloxy)-2,4,6-trimethyl-oct-6-en-1-ol 
• 911708-80-0 (2S,4E)-2,4-dimethylhex-4-en-1-ol 
• 936946-34-8 C₃₀H₄₇NO₅Si 

Downstream Products

• 936946-36-0 (2'S,3'R,4'R,5'S,6'S,8E,4S)-3-[(5-[tert-butyldimethylsilyloxy]-3-triethylsilyloxyl-2,4,6,8-tetramethyl-1-oxo-dec-8-enyl)-4-(phenylmethyl)]-2-oxazolidinone 
• 936946-39-3 C₂₄H₃₅NO₅ 

Relevant academic research and scientific papers

Stereoselective synthesis of the C13-32 spiroacetal fragment of spirangien A

Stereoselective synthesis of an advanced intermediate towards the highly cytotoxic polyketide metabolite spirangien A was achieved. A key step in the synthesis was installation of the C23 stereocentre by a substrate controlled C22-23 aldol reaction. Compa

Synthesis of the C23-C32 fragment of spirangien

The synthesis of the C23-C32 fragment of spirangien A is reported using Evans' alkylation, Evans-Metternich aldol reaction and a substrate controlled stereoselective reduction.