1447755-97-6

Basic information

• Product Name: C₁₂H₁₁F₂N₃O₃
• CAS NO: 1447755-97-6
• Molecular Weight: 283.234
• Mol File: 1447755-97-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₁F₂N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₁F₂N₃O₃(1447755-97-6)
• EPA Substance Registry System: C₁₂H₁₁F₂N₃O₃(1447755-97-6)

Safety Data

• Hazardous Substances Data: 1447755-97-6(Hazardous Substances Data)

Upstream product

• 151103-08-1 4-difluoromethoxy-3-hydroxybenzaldehyde 
• 162401-70-9 4-(difluoromethoxy)-3-methoxybenzaldehyde 
• 74-89-5 methylamine 
• 121-33-5 vanillin 
• 1447755-95-4 5-(4-(difluoromethoxy)-3-hydroxybenzylidene)-2-thioxoimidazolidin-4-one 

Relevant articles and documents

Synthesis and in vitro biological evaluation of novel 2-aminoimidazolone derivatives as anti-tumor agents

Novel 2-aminoimidazolone derivatives were synthesized. Most compounds displayed strong anticancer activities against human carcinoma cells in vitro. Compounds 8a, 8b and 8j exhibited optimal activity superior to 5-FU in most cancer cells tested. Especially, the IC50s of 8b (12.6-21.5 μmol/L) against five tumor cells were 1-4 fold less than those of 5-FU (18.4-56.1 μmol/L) in vitro. Furthermore, compound 8b could induce SMMC-7721 cell apoptosis in a dose-dependent manner. Therefore, our novel findings may provide a new framework for the design of new 2-aminoimidazolone derivatives for the treatment of cancer.