1447759-41-2Relevant academic research and scientific papers
The Aryne aza-Diels-Alder Reaction: Flexible Syntheses of Isoquinolines
Castillo, Juan-Carlos,Quiroga, Jairo,Abonia, Rodrigo,Rodriguez, Jean,Coquerel, Yoann
supporting information, p. 3374 - 3377 (2015/07/15)
(Chemical Equation Presented). Two cascade reactions have been developed for the time-efficient preparation of a variety of functionalized aromatic heterocyclic products exhibiting an isoquinoline core. The approach is based on the normal electron-demand
Divergent chemo-, regio-, and diastereoselective normal electron-demand povarov-type reactions with α-oxo-ketene dienophiles
Galvez, Jaime,Castillo, Juan-Carlos,Quiroga, Jairo,Rajzmann, Michel,Rodriguez, Jean,Coquerel, Yoann
supporting information, p. 4126 - 4129 (2014/10/15)
The reactions between electron-rich 2-aza-dienes and α-oxo-ketenes derived from the Wolff rearrangement of 2-diazocycloalkane-1,3-diones chemo- and regioselectively produced spiro hydropyrid-4-ones with good to excellent diastereoselectivities. These reactions are likely to proceed via a domino Wolff/Friedel-Crafts/intramolecular Mannich process. Prolonged domino sequences also allowed the expeditious preparation of a series of pyrazolopyridine and pyridopyrimidine heterocycles.
Catalyst-free Synthesis of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives by Aza-Diels-Alder reaction
Quiroga, Jairo,Valencia, Angela,Perez, Alfredo,Galvez, Jaime,Abonia, Rodrigo,Insuasty, Braulio
, p. 337 - 341 (2013/07/26)
A series of pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives was synthesized via catalyst-free bi-component and one-pot reactions of 5-Aminopyrazoles, DMF-DMA (or TMOF) and N-Arylmaleimides in xylene as solvent. This protocol showed advantages of milder reaction conditions, easier work-up, shorter reaction times and good yields, over other approaches tested.
