1447815-56-6

Basic information

• Product Name: L-isoseryl-L-valyl-L-phenylalanine
• CAS NO: 1447815-56-6
• Molecular Weight: 351.403
• Mol File: 1447815-56-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-isoseryl-L-valyl-L-phenylalanine(CAS DataBase Reference)
• NIST Chemistry Reference: L-isoseryl-L-valyl-L-phenylalanine(1447815-56-6)
• EPA Substance Registry System: L-isoseryl-L-valyl-L-phenylalanine(1447815-56-6)

Safety Data

• Hazardous Substances Data: 1447815-56-6(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 72-18-4 L-valine 
• 20902-47-0 N-tert-butoxycarbonyl-L-valyl-L-phenylalanine methyl ester 
• 10342-47-9 L-valine-L-phenylalanine methyl ester hydrochloride 
• 13734-41-3 t-Boc-L-valine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 

Relevant articles and documents

Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors

Aminopeptidase N (APN/CD13) is one of the essential proteins for tumour invasion, angiogenesis and metastasis as it is over-expressed on the surface of different tumour cells. Based on our previous work that L-isoserine dipeptide derivatives were potent APN inhibitors, we designed and synthesized L-isoserine tripeptide derivatives as APN inhibitors. Among these compounds, one compound 16l (IC50=2.51±0.2 M) showed similar inhibitory effect compared with control compound Bestatin (IC50=6.25±0.4 M) and it could be used as novel lead compound for the APN inhibitors development as anticancer agents in the future.