144782-92-3Relevant academic research and scientific papers
A New Synthesis of FPL 64176 and Analogues: The Discovery of Benzoylpyrrole Calcium Channel Activators with Low Nanomolar Potency
Baxter, Andrew J. G.,Teague, Simon
, p. 9089 - 9094 (2007/10/02)
Heavy metal assisted halogen displacement on 2-halobenzoylpyrroles (2 and 3) leads to a simple synthesis of FPL 64176 (1) and a variety of analogues (4-10).The difluoro derivative (4), EC 50 1nM, and the amino linked analogue (7), EC 50 2.7nm, are present
An extremely short synthesis of benzoylpyrrole-type calcium channel activators
Dalton, Christopher R.,Kane, John M.,Rampe, David
, p. 5713 - 5716 (2007/10/02)
Friedel-Crafts acylation of methyl 2,5-dimethylpyrrole-3-carboxylate with 2-chloromethylbenzoyl chloride generated the corresponding 4-(2-chloromethylbenzoyl)pyrrole which was reacted in situ with benzene and aluminum chloride to yield the novel calcium c
