144785-52-4Relevant academic research and scientific papers
Research on antiviral agents. 5.1 lithiation of 6-methyluracil as a new and efficient entry to C(6)-substituted uracils
Botta, Maurizio,Saladino, Raffaele,Delle Monache, Giuliano,Gentile, Gabriella,Nicoletti, Rosario
, p. 1687 - 1697 (2007/10/03)
Synthesis of numerous C(6)-substituted uracits can be effected by lithiation of N(1), N(3)-substituted 6-methyluracils (1) and (4) with LiHMDS, followed by the reaction of the resulting lithio derivatives with carbon, sulfur, and selenium electrophiles. The unexpected migration of the N(1)-benzoyl group in the melalation-alkylation and the high stereoselectivity obtained in the reaction with substituted cyclohexanones are also reported.
Cycloaromatization of α-oxoketene dithioacetals with enaminone derived carbanions
Satyanarayana,Reddy,Ila,Junjappa
, p. 6173 - 6176 (2007/10/02)
Lithium enolates 3b and 6b derived from 1,3,6-trimethyluracil (3a) and 3-pyrrolidinocrotonate (6a) undergo regioselective γ-1,4- and γ-1,2-additions respectively with α-oxoketene dithioacetals 7 to yield the corresponding quinazolines and amino substituted aromatic compounds after subsequent cycloaromatization.
