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1447913-55-4

methyl 5-(trifluoromethyl)thiophene-3-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1447913-55-4 Structure

  • Basic information

    1. Product Name: methyl 5-(trifluoromethyl)thiophene-3-carboxylate
    2. Synonyms: methyl 5-(trifluoromethyl)thiophene-3-carboxylate
    3. CAS NO:1447913-55-4
    4. Molecular Formula:
    5. Molecular Weight: 210.177
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1447913-55-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: methyl 5-(trifluoromethyl)thiophene-3-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: methyl 5-(trifluoromethyl)thiophene-3-carboxylate(1447913-55-4)
    11. EPA Substance Registry System: methyl 5-(trifluoromethyl)thiophene-3-carboxylate(1447913-55-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1447913-55-4(Hazardous Substances Data)

1447913-55-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1447913-55-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,7,9,1 and 3 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1447913-55:
(9*1)+(8*4)+(7*4)+(6*7)+(5*9)+(4*1)+(3*3)+(2*5)+(1*5)=184
184 % 10 = 4
So 1447913-55-4 is a valid CAS Registry Number.

1447913-55-4Relevant articles and documents

Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test

Igawa, Hideyuki,Takahashi, Masashi,Ikoma, Minoru,Kaku, Hiromi,Kakegawa, Keiko,Kina, Asato,Aida, Jumpei,Okuda, Shoki,Kawata, Yayoi,Noguchi, Toshihiro,Hotta, Natsu,Yamamoto, Syunsuke,Nakayama, Masaharu,Nagisa, Yasutaka,Kasai, Shizuo,Maekawa, Tsuyoshi

, p. 2504 - 2518 (2016)

To develop non-basic melanin-concentrating hormone receptor 1 (MCHR1) antagonists with a high probability of target selectivity and therapeutic window, we explored neutral bicyclic motifs that could replace the previously reported imidazo[1,2-a]pyridine or 1H-benzimidazole motif. The results indicated that the binding affinity of a chemically neutral 2H-indazole derivative 8a with MCHR1 (hMCHR1: IC50 = 35 nM) was comparable to that of the imidazopyridine and benzimidazole derivatives (1 and 2, respectively) reported so far. However, 8a was positive in the Ames test using TA1537 in S9- condition. Based on a putative intercalation of 8a with DNA, we introduced a sterically-hindering cyclopropyl group on the indazole ring to decrease planarity, which led to the discovery of 1-(2-cyclopropyl-3-methyl-2H-indazol-5-yl)-4-{[5-(trifluoromethyl)thiophen-3-yl]methoxy}pyridin-2(1H)-one 8l without mutagenicity in TA1537. Compound 8l exerted significant antiobesity effects in diet-induced obese F344 rats and exhibited promising safety profile.

HETEROCYCLIC COMPOUND

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Paragraph 0271, (2015/02/02)

Provided is a compound having a melanin-concentrating hormone receptor antagonistic action and is useful as an agent for the prophylaxis or treatment of obesity and the like. A compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

BENZIMIDAZOLE DERIVATIVES AS MCH RECEPTOR ANTAGONISTS

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Page/Page column 233, (2013/07/25)

The present invention provides an aromatic ring compound having a melanin-concentrating hormone receptor antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound represented by the formula (I) wherein each symbol as defined in the specification, or a salt thereof.

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