1447925-35-0Relevant academic research and scientific papers
Convergent de novo synthesis of vineomycinone B2 methyl ester
Chen, Qian,Zhong, Yashan,O'Doherty, George A.
, p. 6806 - 6808 (2013)
An efficient de novo synthesis of vineomycinone B2 methyl ester has been achieved. The longest linear route required only 14 steps from achiral commercially available starting materials (4.0% overall yield). The key transformations included the de novo asymmetric synthesis of two key fragments, which were joined by a convergent late stage Suzuki's glycosylation for the construction of the aryl β-C-glycoside. A subsequent BBr3 one-pot debenzylation, demethylation and air oxidation provided vineomycinone B2 methyl ester.
