1447965-07-2Relevant academic research and scientific papers
Asymmetric synthesis of 1,3-oxazolidines via intramolecular aza-michael addition by bifunctional organocatalysts
Fukata, Yukihiro,Asano, Keisuke,Matsubara, Seijiro
supporting information, p. 355 - 357 (2013/05/09)
A novel synthetic route to optically active 1,3-oxazolidines via formal [3 + 2] cycloaddition in the presence of cinchonaalkaloid- thiourea-based bifunctional organocatalysts is reported. This protocol gives easy access to a wide range of chiral 1,3- oxazolidines. In addition, the results show that bifunctional organocatalysts can effect the intramolecular aza-Michael addition, leading to the asymmetric synthesis of nitrogencontaining heterocycles.
