198012-02-1

Basic information

• Product Name: Benzenesulfonamide, 4-methyl-N-[[4-(trifluoromethyl)phenyl]methylene]-
• CAS NO: 198012-02-1
• Molecular Formula: C15H12F3NO2S
• Molecular Weight: 327.327
• Mol File: 198012-02-1.mol

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-methyl-N-[[4-(trifluoromethyl)phenyl]methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-methyl-N-[[4-(trifluoromethyl)phenyl]methylene]-(198012-02-1)
• EPA Substance Registry System: Benzenesulfonamide, 4-methyl-N-[[4-(trifluoromethyl)phenyl]methylene]-(198012-02-1)

Safety Data

• Hazardous Substances Data: 198012-02-1(Hazardous Substances Data)

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 72360-67-9 1-(diethoxymethyl)-4-(trifluoromethyl)benzene 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 

Downstream Products

• 1032582-93-6 4-methyl-N-(phenyl(4-(trifluoromethyl)phenyl)methyl)benzenesulfonamide 
• 1182624-47-0 2-(4-methylbenzenesulfonyl)-3-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydroisoquinoline 
• 1404439-36-6 C₂₉H₂₂F₃NO₂S 
• 247128-02-5 2,2'-((4-(trifluoromethyl)phenyl)methylene)bis(1H-pyrrole) 

Relevant articles and documents

Palladium-Catalyzed Regioselective and Stereospecific Ring-Opening Suzuki-Miyaura Arylative Cross-Coupling of 2-Arylazetidines with Arylboronic Acids

We have developed a palladium-catalyzed regioselective and enantiospecific ring-opening Suzuki–Miyaura arylative cross-coupling of N-tosyl-2-arylazetidines to give enantioenriched 3,3-diarylpropylamines. This reaction represents an example of transition-metal-catalyzed ring-opening cross-coupling using azetidines as a non-classical alkyl electrophile. Density functional theory rationalized the mechanism of the full catalytic cycle, which consists of the selectivity-determining ring opening of the azetidine, reaction with water, rate-determining transmetalation, and reductive elimination. Transition states of the selectivity-determining ring-opening step were systematically determined by the multi-component artificial force induced reaction (MC-AFIR) method to explain the regioselectivity of the reaction. (Figure presented.).

One-Pot Synthesis of Diazirines and 15N2-Diazirines from Ketones, Aldehydes and Derivatives: Development and Mechanistic Insight

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We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.

Chiral-Directing-Group-Assisted Rhodium(III)-Catalyzed Asymmetric Addition of Inert Arene C?H Bond to Aldimines with Subsequent Intramolecular Cyclization

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Strategic vinyl sulfone nucleophile β-substitution significantly impacts selectivity in Vinylogous Darzens and aza-Darzens reactions

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Iron-based nanomaterials used as magnetic mesoporous nanocomposites to catalyze the preparation of N-sulfonylimines

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A nickel-catalyzed reductive coupling of alkynes and imines using readily available isopropanol as the reducing agent was developed. The use of a sterically bulky and electron-rich carbene ligand (AnIPr) significantly promotes the reaction, providing various multi-substituted allylic amines in 23-89% yield and the corresponding chiral ligand (AnIPr-3) can afford the products in 51-95% ee.