1448138-38-2Relevant academic research and scientific papers
Dual nucleophilic/electrophilic capture of in situ generated iminium ethers: Towards the synthesis of functionalized amide building blocks
Peng, Bo,O'Donovan, Daniel H.,Jurberg, Igor D.,Maulide, Nuno
, p. 16292 - 16296 (2012)
Rearranging its feathers: The transformation of simple linear amides into a diverse range of branched, functionalized products by conversion to iminium esters is followed by sequential treatment with nucleophiles and electrophiles (see scheme). The method takes advantage of a novel Claisen rearrangement and the use of aromatic substrates greatly facilitates the formation of the intermediate iminium ether.
