1448154-16-2Relevant academic research and scientific papers
Manganese-Catalyzed Multicomponent Synthesis of Pyrroles through Acceptorless Dehydrogenation Hydrogen Autotransfer Catalysis: Experiment and Computation
Borghs, Jannik C.,Azofra, Luis Miguel,Biberger, Tobias,Linnenberg, Oliver,Cavallo, Luigi,Rueping, Magnus,El-Sepelgy, Osama
, p. 3083 - 3088 (2019)
A new base metal catalyzed sustainable multicomponent synthesis of pyrroles from readily available substrates is reported. The developed protocol utilizes an air- and moisture-stable catalyst system and enables the replacement of themutagenic α-haloketones with readily abundant 1,2-diols. Moreover, the presented method is catalytic in base and the sole byproducts of this transformation are water and hydrogen gas. Experimental and computational mechanistic studies indicate that the reaction takes place through a combined acceptorless dehydrogenation hydrogen autotransfer methodology.
General and regioselective synthesis of pyrroles via ruthenium-catalyzed multicomponent reactions
Zhang, Min,Fang, Xianjie,Neumann, Helfried,Beller, Matthias
supporting information, p. 11384 - 11388 (2013/08/23)
A general and highly regioselective synthesis of pyrroles via ruthenium-catalyzed three-component reactions has been developed. A variety of ketones including less reactive aryl and alkyl substrates were efficiently converted in combination with different
