1448175-33-4Relevant academic research and scientific papers
An efficient catalytic method for regioselective sulfenylation of electron-rich aza-aromatics at room temperature
Marcantoni, Enrico,Cipolletti, Roberto,Marsili, Laura,Menichetti, Stefano,Properzi, Roberta,Viglianisi, Caterina
, p. 132 - 140 (2013/02/22)
Electron-rich aza-aromatic compounds such as indoles and pyrroles are structures of particular interest and importance in organic chemistry. A useful methodology for the regioselective introduction of the sulfenyl group into electron-rich aza-aromatics using S-alkyl- and S-arylthiophthalimides as sulfenylating agents is described. Catalytic amounts of CeCl3· 7H2O/NaI are crucial to the promotion of this regioselective carbon-sulfur-bond-forming electrophilic aromatic substitution reaction. The reaction occurred under mild conditions, and the products were obtained in good to excellent yields. The method represents an efficient preparation of sulfenyl aza-aromatics, which are useful intermediates for important organic transformations, due to the great importance of functionalized indoles among natural compounds and pharmaceutical products. A useful method for the regioselective introduction of the sulfenyl group into electron-rich aza-aromatics using S-alkyl- and S-arylthiophthalimides as sulfenylating agents is described. Catalytic amounts of CeCl3·7H2O/NaI are crucial to the promotion of this regioselective carbon-sulfur-bond-forming electrophilic aromatic substitution reaction. Copyright
