178161-08-5

Upstream product

• 54974-07-1 phthalimidesulfenyl chloride 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 1046446-83-6 4-(6-methoxy-2,3-dihydrobenzo[1,4]oxathiin-2-yl)phenol 
• 1627688-34-9 C₂₇H₄₂O₄SSi₂ 
• 1627688-35-0 C₂₁H₂₈O₃SSi 
• 1448175-33-4 2-(1H-indol-3-ylthio)-4-methoxyphenol 
• 1448175-40-3 4-methoxy-2-(1-methyl-1H-pyrrol-2-ylthio)phenol 
• 1448175-39-0 4-methoxy-2-(1H-pyrrol-2-ylthio)phenol 

Relevant academic research and scientific papers

Thiaflavan scavenges radicals and inhibits DNA oxidation: A story from the ferrocene modification

4-Thiaflavan is a sulfur-substituted flavonoid with a benzoxathiin scaffold. The aim of this work is to compare abilities of sulfur and oxygen atom, hydroxyl groups, and ferrocene moiety at different positions of 4-thiaflavan to trap radicals and to inhibit DNA oxidation. It is found that abilities of thiaflavans to trap radicals and to inhibit DNA oxidation are increased in the presence of ferrocene moiety and are further improved by the electron-donating group attaching to thiaflavan skeleton. It can be concluded that the ferrocene moiety plays the major role for thiaflavans to be antioxidants even in the absence of phenolic hydroxyl groups. On the other hand, the antioxidant effectiveness of phenolic hydroxyl groups in thiaflavans can be improved by the electron-donating group. The influences of sulfur and oxygen atoms in thiaflavans on the antioxidant property of para-hydroxyl group exhibit different manners when the thiaflavans are used to trap radicals and to inhibit DNA oxidation.

Phthalimidesulfenyl chloride. x1. a synthetic equivalent of hs+ and+s-s+ species in electrophilic aromatic substitutions

The reaction of phthalimidesulfenyl chloride, 1, with activated arenes provides monosubstituted phthalimidesulfenyl derivatives 3 which can be easily transformed into the corresponding disulfides 7, thiols 8 and masked thiols 9.